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Cognitive fluctuations in Parkinson’s disease dementia: blood pressure lability as an underlying mechanism

Overview of attention for article published in Journal of Clinical Movement Disorders, February 2018
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Title
Cognitive fluctuations in Parkinson’s disease dementia: blood pressure lability as an underlying mechanism
Published in
Journal of Clinical Movement Disorders, February 2018
DOI 10.1186/s40734-018-0068-4
Pubmed ID
Authors

David E. Riley, Alberto J. Espay

Abstract

Cognitive fluctuations refer to alterations in cognition, attention, or arousal occurring over minutes to hours, most commonly in patients with dementias associated with advanced Lewy body pathology. Their pathophysiologic underpinning remains undetermined. We documented serial blood pressure (BP) measurements in an 86-year-old man with Parkinson's disease dementia experiencing cognitive fluctuations during an office visit. This patient's associated dysautonomia included labile BP with orthostatic hypotension and nocturnal hypertension. A spontaneous episode of unresponsiveness occurred while his BP was 72/48. His mental status began to recover immediately as his BP increased to 84/56 when he was placed in a recumbent position; it fully returned to baseline when it reached 124/66 within 1 min. His heart rate remained in the mid-to-high 60s throughout. Subsequent treatment with midodrine markedly reduced the frequency of cognitive fluctuations. Paroxysmal hypotension may represent an explanatory mechanism for cognitive fluctuations, a common clinical feature in patients with Parkinson's disease dementia and dementia with Lewy bodies.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 17%
Student > Bachelor 4 14%
Student > Master 4 14%
Student > Doctoral Student 2 7%
Other 2 7%
Other 6 21%
Unknown 6 21%
Readers by discipline Count As %
Medicine and Dentistry 9 31%
Neuroscience 5 17%
Biochemistry, Genetics and Molecular Biology 2 7%
Psychology 2 7%
Agricultural and Biological Sciences 1 3%
Other 1 3%
Unknown 9 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2018.
All research outputs
#18,587,406
of 23,023,224 outputs
Outputs from Journal of Clinical Movement Disorders
#45
of 64 outputs
Outputs of similar age
#334,984
of 446,078 outputs
Outputs of similar age from Journal of Clinical Movement Disorders
#2
of 2 outputs
Altmetric has tracked 23,023,224 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 64 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,078 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.