Title |
Clinical evaluation of two different protein content formulas fed to full-term healthy infants: a randomized controlled trial
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Published in |
BMC Pediatrics, February 2018
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DOI | 10.1186/s12887-018-1046-6 |
Pubmed ID | |
Authors |
Nadia Liotto, Anna Orsi, Camilla Menis, Pasqua Piemontese, Laura Morlacchi, Chiara Cristiana Condello, Maria Lorella Giannì, Paola Roggero, Fabio Mosca |
Abstract |
A high early protein intake is associated with rapid postnatal weight gain and altered body composition. We aimed to evaluate the safety of a low-protein formula in healthy full-term infants. A randomized controlled trial was conducted. A total of 118 infants were randomized to receive two different protein content formulas (formula A or formula B (protein content: 1.2 vs. 1.7 g/100 mL, respectively)) for the first 4 months of life. Anthropometry and body composition by air displacement plethysmography were assessed at enrolment and at two and 4 months. The reference group comprised 50 healthy, exclusively breastfed, full-term infants. Weight gain (g/day) throughout the study was similar between the formula groups (32.5 ± 6.1 vs. 32.8 ± 6.8) and in the reference group (30.4 ± 5.4). The formula groups showed similar body composition but a different fat-free mass content from breastfed infants at two and 4 months. However, the formula A group showed a fat-free mass increase more similar to that of the breastfed infants. The occurrence of gastrointestinal symptoms or adverse events was similar between the formula groups. Feeding a low-protein content formula appears to be safe and to promote adequate growth, although determination of the long-term effect on body composition requires further study. The present study was retrospectively registered in ClinicalTrials.gov (trial number: NCT03035721 on January 18, 2017). |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 68 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 10 | 15% |
Student > Master | 7 | 10% |
Student > Ph. D. Student | 6 | 9% |
Lecturer | 4 | 6% |
Researcher | 4 | 6% |
Other | 12 | 18% |
Unknown | 25 | 37% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 14 | 21% |
Nursing and Health Professions | 10 | 15% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Unspecified | 2 | 3% |
Agricultural and Biological Sciences | 2 | 3% |
Other | 8 | 12% |
Unknown | 27 | 40% |