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Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1) – distinct characteristics in neurons

Overview of attention for article published in BMC Molecular and Cell Biology, June 2007
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Title
Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1) – distinct characteristics in neurons
Published in
BMC Molecular and Cell Biology, June 2007
DOI 10.1186/1471-2121-8-22
Pubmed ID
Authors

Annina Lyly, Carina von Schantz, Tarja Salonen, Outi Kopra, Jani Saarela, Matti Jauhiainen, Aija Kyttälä, Anu Jalanko

Abstract

Neuronal ceroid lipofuscinoses (NCLs) are collectively the most common type of recessively inherited childhood encephalopathies. The most severe form of NCL, infantile neuronal ceroid lipofuscinosis (INCL), is caused by mutations in the CLN1 gene, resulting in a deficiency of the lysosomal enzyme, palmitoyl protein thioesterase 1 (PPT1). The deficiency of PPT1 causes a specific death of neocortical neurons by a mechanism, which is currently unclear. To understand the function of PPT1 in more detail, we have further analyzed the basic properties of the protein, especially focusing on possible differences in non-neuronal and neuronal cells.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 33%
Student > Ph. D. Student 9 20%
Student > Bachelor 5 11%
Other 3 7%
Student > Postgraduate 3 7%
Other 5 11%
Unknown 5 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 24%
Medicine and Dentistry 8 18%
Biochemistry, Genetics and Molecular Biology 6 13%
Chemistry 3 7%
Neuroscience 3 7%
Other 5 11%
Unknown 9 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2008.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from BMC Molecular and Cell Biology
#334
of 1,233 outputs
Outputs of similar age
#29,569
of 82,461 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#7
of 22 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 82,461 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.