Report for: A concise synthesis of Fingolimod: an orally available drug for treating multiple sclerosis

Title	A concise synthesis of Fingolimod: an orally available drug for treating multiple sclerosis
Published in	BMC Chemistry, February 2015
DOI	10.1186/s13065-015-0081-8
Pubmed ID	25657817
Authors	Ning Yan, Kai Chen, Xinfa Bai, Lei Bi, Lei Yao
Abstract	A concise route for the synthesis of Fingolimod is reported. Starting from n-octylbenzene and 3-nitropropionic acid, a sequence of reactions consisting of Friedel-Crafts acylation, reduction, and double Henry reaction, followed by hydrogenation were applied to prepare Fingolimod with a yield of 31%, and an overall atom economy of 82.7%. Graphical AbstractStarting from 3-nitropropanyl chloride, Fingolimod was obtained in 4 steps with an overall yield of 31%.

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Unknown	21	100%

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Student > Master	4	19%
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Unknown	8	38%

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A concise synthesis of Fingolimod: an orally available drug for treating multiple sclerosis