Title |
Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria
|
---|---|
Published in |
Malaria Journal, February 2002
|
DOI | 10.1186/1475-2875-1-1 |
Pubmed ID | |
Authors |
Quinton L Fivelman, Geoffrey A Butcher, Ipemida S Adagu, David C Warhurst, Geoffrey Pasvol |
Abstract |
We report the first in vitro and genetic confirmation of Malarone (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a male patient was given a standard 3-day treatment course of Malarone. Twenty-eight days later the parasitaemia recrudesced. Parasites were cultured from the blood and the isolate (NGATV01) was shown to be resistant to atovaquone and the antifolate pyrimethamine. The cytochrome b gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Ecuador | 1 | <1% |
Unknown | 198 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 6% |
Student > Master | 8 | 4% |
Student > Bachelor | 7 | 4% |
Student > Ph. D. Student | 6 | 3% |
Student > Doctoral Student | 4 | 2% |
Other | 11 | 6% |
Unknown | 152 | 76% |
Readers by discipline | Count | As % |
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Economics, Econometrics and Finance | 3 | 2% |
Other | 13 | 7% |
Unknown | 153 | 77% |