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Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria

Overview of attention for article published in Malaria Journal, February 2002
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4 Wikipedia pages

Citations

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199 Mendeley
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Title
Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria
Published in
Malaria Journal, February 2002
DOI 10.1186/1475-2875-1-1
Pubmed ID
Authors

Quinton L Fivelman, Geoffrey A Butcher, Ipemida S Adagu, David C Warhurst, Geoffrey Pasvol

Abstract

We report the first in vitro and genetic confirmation of Malarone (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a male patient was given a standard 3-day treatment course of Malarone. Twenty-eight days later the parasitaemia recrudesced. Parasites were cultured from the blood and the isolate (NGATV01) was shown to be resistant to atovaquone and the antifolate pyrimethamine. The cytochrome b gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ecuador 1 <1%
Unknown 198 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 6%
Student > Master 8 4%
Student > Bachelor 7 4%
Student > Ph. D. Student 6 3%
Student > Doctoral Student 4 2%
Other 11 6%
Unknown 152 76%
Readers by discipline Count As %
Medicine and Dentistry 13 7%
Agricultural and Biological Sciences 8 4%
Social Sciences 6 3%
Nursing and Health Professions 3 2%
Economics, Econometrics and Finance 3 2%
Other 13 7%
Unknown 153 77%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2019.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from Malaria Journal
#2,546
of 5,918 outputs
Outputs of similar age
#31,210
of 126,872 outputs
Outputs of similar age from Malaria Journal
#1
of 2 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,918 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 126,872 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them