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Dominant integration locus drives continuous diversification of plant immune receptors with exogenous domain fusions

Overview of attention for article published in Genome Biology (Online Edition), February 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)

Mentioned by

news
6 news outlets
blogs
1 blog
twitter
48 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
89 Dimensions

Readers on

mendeley
102 Mendeley
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Title
Dominant integration locus drives continuous diversification of plant immune receptors with exogenous domain fusions
Published in
Genome Biology (Online Edition), February 2018
DOI 10.1186/s13059-018-1392-6
Pubmed ID
Authors

Paul C. Bailey, Christian Schudoma, William Jackson, Erin Baggs, Gulay Dagdas, Wilfried Haerty, Matthew Moscou, Ksenia V. Krasileva

Abstract

The plant immune system is innate and encoded in the germline. Using it efficiently, plants are capable of recognizing a diverse range of rapidly evolving pathogens. A recently described phenomenon shows that plant immune receptors are able to recognize pathogen effectors through the acquisition of exogenous protein domains from other plant genes. We show that plant immune receptors with integrated domains are distributed unevenly across their phylogeny in grasses. Using phylogenetic analysis, we uncover a major integration clade, whose members underwent repeated independent integration events producing diverse fusions. This clade is ancestral in grasses with members often found on syntenic chromosomes. Analyses of these fusion events reveals that homologous receptors can be fused to diverse domains. Furthermore, we discover a 43 amino acid long motif associated with this dominant integration clade which is located immediately upstream of the fusion site. Sequence analysis reveals that DNA transposition and/or ectopic recombination are the most likely mechanisms of formation for nucleotide binding leucine rich repeat proteins with integrated domains. The identification of this subclass of plant immune receptors that is naturally adapted to new domain integration will inform biotechnological approaches for generating synthetic receptors with novel pathogen "baits."

Twitter Demographics

The data shown below were collected from the profiles of 48 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 102 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 24%
Researcher 18 18%
Student > Doctoral Student 8 8%
Student > Bachelor 7 7%
Student > Postgraduate 6 6%
Other 15 15%
Unknown 24 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 49 48%
Biochemistry, Genetics and Molecular Biology 17 17%
Environmental Science 2 2%
Nursing and Health Professions 1 <1%
Pharmacology, Toxicology and Pharmaceutical Science 1 <1%
Other 5 5%
Unknown 27 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 79. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2018.
All research outputs
#373,058
of 19,844,828 outputs
Outputs from Genome Biology (Online Edition)
#269
of 3,875 outputs
Outputs of similar age
#10,561
of 290,052 outputs
Outputs of similar age from Genome Biology (Online Edition)
#1
of 1 outputs
Altmetric has tracked 19,844,828 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,875 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.9. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,052 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them