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Prevalence of extended-spectrum-β-lactamase-producing Enterobacteriaceae: first systematic meta-analysis report from Pakistan

Overview of attention for article published in Antimicrobial Resistance & Infection Control, February 2018
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Title
Prevalence of extended-spectrum-β-lactamase-producing Enterobacteriaceae: first systematic meta-analysis report from Pakistan
Published in
Antimicrobial Resistance & Infection Control, February 2018
DOI 10.1186/s13756-018-0309-1
Pubmed ID
Authors

Samyyia Abrar, Shahida Hussain, Rehan Ahmad Khan, Noor Ul Ain, Hayat Haider, Saba Riaz

Abstract

South-Asia is known as a hub for multidrug-resistant (MDR) bacteria. Unfortunately, proper surveillance and documentation of MDR pathogens is lacking in Pakistan. The alarming increase in the prevalence of extended-spectrum β-lactamase (ESBL)-producingEnterobacteriaceaeis a serious problem. From this perspective, we analysed published data regarding ESBL-producingEnterobacteriaceaein different regions of Pakistan. A meta-analysis was performed to determine the prevalence of ESBL-producingEnterobacteriaceaein Pakistan. A Web-based search was conducted in electronic databases, including PubMed, Scopus and PakMedi Net (for non-indexed Pakistani journals). Articles published (in either indexed or non-indexed journals) between January 2002 and July 2016 were included in the study. Relevant data were extracted, and statistical analysis was performed using theMetapropcommand of STATA version 14.1. A total of 68 studies were identified from the electronic data base search, and 55 of these studies met our inclusion criteria. Pakistan's overall pooled proportion of ESBL-producers was 0.40 (95% CI: 0.34-0.47). The overall heterogeneity was significant (I2 = 99.75%,p < 0.001), and significant ES = 0 (Z = 18.41,p < 0.001) was found. OXA, SHV, TEM and CTX-M were the most commonly found gene variants for ESBLs in these studies. The prevalence of ESBL-producingEnterobacteriaceaeis high in Pakistan. Little is known about the annual frequency of ESBLs and their prevalence in different provinces of Pakistan. No data are available regarding ESBL frequency in Baluchistan. This underscores an urgent demand for regular surveillance to address this antimicrobial resistance problem. Surveillance to better understand the annual ESBL burden is crucial to improve national and regional guidelines.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 107 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 16%
Researcher 15 14%
Student > Ph. D. Student 9 8%
Student > Bachelor 8 7%
Student > Doctoral Student 5 5%
Other 18 17%
Unknown 35 33%
Readers by discipline Count As %
Immunology and Microbiology 19 18%
Medicine and Dentistry 15 14%
Biochemistry, Genetics and Molecular Biology 11 10%
Agricultural and Biological Sciences 6 6%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Other 14 13%
Unknown 38 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2018.
All research outputs
#16,287,458
of 24,003,070 outputs
Outputs from Antimicrobial Resistance & Infection Control
#1,065
of 1,347 outputs
Outputs of similar age
#214,472
of 334,215 outputs
Outputs of similar age from Antimicrobial Resistance & Infection Control
#45
of 48 outputs
Altmetric has tracked 24,003,070 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,347 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.