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Effects of different extracts of curcumin on TPC1 papillary thyroid cancer cell line

Overview of attention for article published in BMC Complementary and Alternative Medicine, February 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)

Mentioned by

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2 tweeters

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43 Mendeley
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Title
Effects of different extracts of curcumin on TPC1 papillary thyroid cancer cell line
Published in
BMC Complementary and Alternative Medicine, February 2018
DOI 10.1186/s12906-018-2125-9
Pubmed ID
Authors

Angelica Perna, Antonio De Luca, Laura Adelfi, Tammaro Pasquale, Bruno Varriale, Teresa Esposito

Abstract

The thyroid gland is one of the largest endocrine glands in the body. The vast majority of TCs (> 90%) originate from follicular cells and are defined as differentiated thyroid cancers (DTC) and the two histological subtypes are the papillary TC with its variants and the follicular TC. Curcumin possesses a wide variety of biological functions, and thanks to its properties, it has gained considerable attention due to its profound medicinal values (Prasad, Gupta, Tyagi, and Aggarwal, Biotechnol Adv 32:1053-1064, 2014). We have undertaken the present work in order to define the possible role of curcumin in modulating the genetic expression of cell markers and to understand the effectiveness of this nutraceutical in modulating the regression of cancer phenotype. As a template we used the TPC-1 cells treated with the different extracts of turmeric, and examined the levels of expression of different markers (proliferative, inflammatory, antioxidant, apoptotic). Treatment with the three different curcumin extracts displays anti-inflammatory, antioxidant properties and it is able to influence cell cycle with slightly different effects upon the extracts. Furthermore curcumin is able to influence cell metabolic activity vitality. In conclusion curcumin has the potential to be developed as a safe therapeutic but further studies are needed to verify its antitumor ability in vivo.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 19%
Student > Master 5 12%
Professor > Associate Professor 4 9%
Student > Postgraduate 4 9%
Student > Ph. D. Student 3 7%
Other 8 19%
Unknown 11 26%
Readers by discipline Count As %
Medicine and Dentistry 7 16%
Pharmacology, Toxicology and Pharmaceutical Science 7 16%
Nursing and Health Professions 5 12%
Biochemistry, Genetics and Molecular Biology 4 9%
Chemical Engineering 2 5%
Other 4 9%
Unknown 14 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2019.
All research outputs
#8,438,417
of 15,335,820 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,150
of 2,963 outputs
Outputs of similar age
#128,361
of 276,763 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#1
of 1 outputs
Altmetric has tracked 15,335,820 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,963 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,763 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them