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Adipo/cytokines in atherosclerotic secretomes: increased visfatin levels in unstable carotid plaque

Overview of attention for article published in BMC Cardiovascular Disorders, July 2016
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Title
Adipo/cytokines in atherosclerotic secretomes: increased visfatin levels in unstable carotid plaque
Published in
BMC Cardiovascular Disorders, July 2016
DOI 10.1186/s12872-016-0320-5
Pubmed ID
Authors

Teresa Auguet, Gemma Aragonès, Esther Guiu-Jurado, Alba Berlanga, Marta Curriu, Salomé Martinez, Ajla Alibalic, Carmen Aguilar, María-Luisa Camara, Esteban Hernández, Xavier Ruyra, Vicente Martín-Paredero, Cristóbal Richart

Abstract

Novel pro-inflammatory and anti-inflammatory derivatives from adipose tissue, known as adipokines, act as metabolic factors. The aim of this study was to analyse the secreted expression of different adipo/cytokines in secretomes of unstable carotid atherosclerotic plaque versus non-atherosclerotic mammary artery. We evaluated the secretion levels of adiponectin, visfatin, lipocalin-2, resistin, IL-6 and TNFR2 by ELISA in human secretomes from cultured unstable carotid atherosclerotic plaque (n = 18) and non-atherosclerotic mammary artery (n = 13). We also measured visfatin serum levels in patients suffering from atherosclerosis and in a serum cohort of healthy subjects (n = 16). We found that visfatin levels were significantly increased in unstable carotid atherosclerotic plaque secretome than in non-atherosclerotic mammary artery secretome. No differences were found with regard the other adipo/cytokines studied. Regarding visfatin circulating levels, there were no differences between unstable carotid atherosclerotic plaque and non-atherosclerotic mammary artery group. However, these visfatin levels were increased in comparison to serum cohort of healthy subjects. Of all the adipo/cytokines analysed, only visfatin showed increased levels in secretomes of unstable carotid atherosclerotic plaque. Additional human studies are needed to clarify the possible role of visfatin as prognostic factor of unstable carotid atherosclerotic plaque.

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Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 4%
Netherlands 1 4%
Unknown 24 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 19%
Student > Bachelor 5 19%
Professor > Associate Professor 3 12%
Professor 2 8%
Student > Doctoral Student 1 4%
Other 5 19%
Unknown 5 19%
Readers by discipline Count As %
Medicine and Dentistry 11 42%
Biochemistry, Genetics and Molecular Biology 4 15%
Unspecified 1 4%
Nursing and Health Professions 1 4%
Business, Management and Accounting 1 4%
Other 2 8%
Unknown 6 23%