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Maitotoxin-induced membrane blebbing and cell death in bovine aortic endothelial cells

Overview of attention for article published in BMC Physiology, February 2001
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6 Wikipedia pages

Citations

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Title
Maitotoxin-induced membrane blebbing and cell death in bovine aortic endothelial cells
Published in
BMC Physiology, February 2001
DOI 10.1186/1472-6793-1-2
Pubmed ID
Authors

Mark Estacion, William P Schilling

Abstract

Maitotoxin, a potent cytolytic agent, causes an increase in cytosolic free Ca2+ concentration ([Ca2+]i) via activation of Ca2+-permeable, non-selective cation channels (CaNSC). Channel activation is followed by formation of large endogenous pores that allow ethidium and propidium-based vital dyes to enter the cell. Although activation of these cytolytic/oncotic pores, or COP, precedes release of lactate dehydrogenase, an indication of oncotic cell death, the relationship between CaNSC, COP, membrane lysis, and the associated changes in cell morphology has not been clearly defined. In the present study, the effect maitotoxin on [Ca2+]i, vital dye uptake, lactate dehydrogenase release, and membrane blebbing was examined in bovine aortic endothelial cells.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 13%
United States 1 13%
Portugal 1 13%
French Polynesia 1 13%
Unknown 4 50%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 63%
Student > Ph. D. Student 5 63%
Professor > Associate Professor 3 38%
Student > Master 3 38%
Student > Doctoral Student 2 25%
Other 3 38%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 88%
Medicine and Dentistry 3 38%
Pharmacology, Toxicology and Pharmaceutical Science 2 25%
Chemistry 2 25%
Biochemistry, Genetics and Molecular Biology 1 13%
Other 4 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2022.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from BMC Physiology
#32
of 88 outputs
Outputs of similar age
#26,115
of 113,854 outputs
Outputs of similar age from BMC Physiology
#1
of 2 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 88 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 113,854 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them