↓ Skip to main content

Insulin receptor sensitization restores neocortical excitation/inhibition balance in a mouse model of autism

Overview of attention for article published in Molecular Autism, February 2018
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age

Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
6 Dimensions

Readers on

mendeley
28 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Insulin receptor sensitization restores neocortical excitation/inhibition balance in a mouse model of autism
Published in
Molecular Autism, February 2018
DOI 10.1186/s13229-018-0196-6
Pubmed ID
Authors

Fu-Sun Lo, Reha S. Erzurumlu

Abstract

Met receptor tyrosine kinase regulates neurogenesis, differentiation, migration, connectivity, and synaptic plasticity. The humanMetgene has been identified as a prominent risk factor for autism spectrum disorder (ASD). Met gene-altered mice serve as useful models for mechanistic studies of ASD. Inactivation ofMetin excitatory cortical neurons in mice (Emx1 cre /Met flox mice) yields a phenotype in which significantly decreased GABAAreceptor-mediated inhibition shifts the excitation/inhibition (E/I) balance toward excitation in the somatosensory cortex. Further, unlike that seen in wild-type mice, insulin does not increase inhibition in the mutant cortex, suggesting that one of the consequences of kinase inactiveMetgene could be desensitization of insulin receptors. To test this hypothesis, we investigated the effects of insulin receptor sensitizer, pioglitazone, on inhibition in the somatosensory thalamocortical circuitry. We used whole-cell patch clamp electrophysiology and analyzed excitatory and inhibitory responses of cortical layer IV excitatory cells following stimulation of their thalamic input in thalamocortical pathway intact brain slices. We applied insulin alone and insulin + a thiazolidinedione, pioglitazone (PIO), to test the effects of sensitizing insulin receptors on inhibitory responses mediated by GABAAreceptors in the somatosensory cortex ofEmx1 cre /Met flox mice. In WT brain slices, application of insulin together with PIO did not enhance the effect of insulin alone. In contrast, PIO application induced a much larger inhibition than that of insulin alone inMet-defective cortex. Thus, insulin resistance of GABAAreceptor-mediated response inMetmutant mice may result from desensitized insulin receptors. Sporadic clinical studies reported improved behavioral symptoms in children with autism following PIO treatment. We show that PIO can aid in normalization of the E/I balance in the primary somatosensory cortex, a potential physiological mechanism underlying the positive effects of PIO treatment.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 18%
Researcher 5 18%
Student > Ph. D. Student 5 18%
Other 3 11%
Unspecified 1 4%
Other 1 4%
Unknown 8 29%
Readers by discipline Count As %
Neuroscience 9 32%
Biochemistry, Genetics and Molecular Biology 3 11%
Psychology 2 7%
Arts and Humanities 1 4%
Unspecified 1 4%
Other 1 4%
Unknown 11 39%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2018.
All research outputs
#8,770,105
of 15,549,387 outputs
Outputs from Molecular Autism
#428
of 508 outputs
Outputs of similar age
#134,238
of 277,220 outputs
Outputs of similar age from Molecular Autism
#1
of 1 outputs
Altmetric has tracked 15,549,387 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 508 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.9. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,220 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them