Title |
The F-box protein family
|
---|---|
Published in |
Genome Biology, November 2000
|
DOI | 10.1186/gb-2000-1-5-reviews3002 |
Pubmed ID | |
Authors |
Edward T Kipreos, Michele Pagano |
Abstract |
The F-box is a protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction. F-box proteins were first characterized as components of SCF ubiquitin-ligase complexes (named after their main components, Skp I, Cullin, and an F-box protein), in which they bind substrates for ubiquitin-mediated proteolysis. The F-box motif links the F-box protein to other components of the SCF complex by binding the core SCF component Skp I. F-box proteins have more recently been discovered to function in non-SCF protein complexes in a variety of cellular functions. There are 11 F-box proteins in budding yeast, 326 predicted in Caenorhabditis elegans, 22 in Drosophila, and at least 38 in humans. F-box proteins often include additional carboxy-terminal motifs capable of protein-protein interaction; the most common secondary motifs in yeast and human F-box proteins are WD repeats and leucine-rich repeats, both of which have been found to bind phosphorylated substrates to the SCF complex. The majority of F-box proteins have other associated motifs, and the functions of most of these proteins have not yet been defined. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 1% |
United Kingdom | 2 | <1% |
Germany | 1 | <1% |
Hungary | 1 | <1% |
Belgium | 1 | <1% |
Colombia | 1 | <1% |
Unknown | 426 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 108 | 25% |
Researcher | 63 | 14% |
Student > Bachelor | 62 | 14% |
Student > Master | 48 | 11% |
Student > Doctoral Student | 20 | 5% |
Other | 60 | 14% |
Unknown | 77 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 178 | 41% |
Biochemistry, Genetics and Molecular Biology | 123 | 28% |
Chemistry | 10 | 2% |
Neuroscience | 10 | 2% |
Medicine and Dentistry | 10 | 2% |
Other | 18 | 4% |
Unknown | 89 | 20% |