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Anaphylatoxin C3a receptors in asthma

Overview of attention for article published in Respiratory Research, February 2005
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2 Wikipedia pages


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29 Mendeley
1 CiteULike
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Anaphylatoxin C3a receptors in asthma
Published in
Respiratory Research, February 2005
DOI 10.1186/1465-9921-6-19
Pubmed ID

Hydar Ali, Reynold A Panettieri


The complement system forms the central core of innate immunity but also mediates a variety of inflammatory responses. Anaphylatoxin C3a, which is generated as a byproduct of complement activation, has long been known to activate mast cells, basophils and eosinophils and to cause smooth muscle contraction. However, the role of C3a in the pathogenesis of allergic asthma remains unclear. In this review, we examine the role of C3a in promoting asthma. Following allergen challenge, C3a is generated in the lung of subjects with asthma but not healthy subjects. Furthermore, deficiency in C3a generation or in G protein coupled receptor for C3a abrogates allergen-induced responses in murine models of pulmonary inflammation and airway hyperresponsiveness. In addition, inhibition of complement activation or administration of small molecule inhibitors of C3a receptor after sensitization but before allergen challenge inhibits airway responses. At a cellular level, C3a stimulates robust mast cell degranulation that is greatly enhanced following cell-cell contact with airway smooth muscle (ASM) cells. Therefore, C3a likely plays an important role in asthma primarily by regulating mast cell-ASM cell interaction.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 3%
Taiwan 1 3%
Unknown 27 93%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 21%
Student > Ph. D. Student 4 14%
Researcher 4 14%
Student > Master 3 10%
Student > Doctoral Student 2 7%
Other 5 17%
Unknown 5 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 24%
Medicine and Dentistry 6 21%
Biochemistry, Genetics and Molecular Biology 4 14%
Immunology and Microbiology 2 7%
Unspecified 1 3%
Other 3 10%
Unknown 6 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2011.
All research outputs
of 22,786,691 outputs
Outputs from Respiratory Research
of 2,745 outputs
Outputs of similar age
of 59,234 outputs
Outputs of similar age from Respiratory Research
of 11 outputs
Altmetric has tracked 22,786,691 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,745 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 59,234 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.