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Protein prenyltransferases

Overview of attention for article published in Genome Biology (Online Edition), April 2003
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (60th percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

dimensions_citation
100 Dimensions

Readers on

mendeley
120 Mendeley
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Title
Protein prenyltransferases
Published in
Genome Biology (Online Edition), April 2003
DOI 10.1186/gb-2003-4-4-212
Pubmed ID
Authors

Sebastian Maurer-Stroh, Stefan Washietl, Frank Eisenhaber

Abstract

Three different protein prenyltransferases (farnesyltransferase and geranylgeranyltransferases I and II) catalyze the attachment of prenyl lipid anchors 15 or 20 carbons long to the carboxyl termini of a variety of eukaryotic proteins. Farnesyltransferase and geranylgeranyltransferase I both recognize a 'Ca1a2X' motif on their protein substrates; geranylgeranyltransferase II recognizes a different, non-CaaX motif. Each enzyme has two subunits. The genes encoding CaaX protein prenyltransferases are considerably longer than those encoding non-CaaX subunits, as a result of longer introns. Alternative splice forms are predicted to occur, but the extent to which each splice form is translated and the functions of the different resulting isoforms remain to be established. Farnesyltransferase-inhibitor drugs have been developed as anti-cancer agents and may also be able to treat several other diseases. The effects of these inhibitors are complicated, however, by the overlapping substrate specificities of geranylgeranyltransferase I and farnesyltransferase.

Mendeley readers

The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
United Kingdom 1 <1%
Canada 1 <1%
Mexico 1 <1%
Trinidad and Tobago 1 <1%
United States 1 <1%
Unknown 114 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 25%
Researcher 24 20%
Student > Bachelor 11 9%
Professor 10 8%
Student > Doctoral Student 10 8%
Other 28 23%
Unknown 7 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 48 40%
Biochemistry, Genetics and Molecular Biology 29 24%
Chemistry 13 11%
Medicine and Dentistry 7 6%
Immunology and Microbiology 4 3%
Other 10 8%
Unknown 9 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2010.
All research outputs
#5,994,569
of 18,439,562 outputs
Outputs from Genome Biology (Online Edition)
#2,846
of 3,726 outputs
Outputs of similar age
#93,178
of 302,170 outputs
Outputs of similar age from Genome Biology (Online Edition)
#6
of 6 outputs
Altmetric has tracked 18,439,562 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,726 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.7. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 302,170 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.