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Gamma-aminobutyric acid-B limbic encephalitis and asystolic cardiac arrest: a case report

Overview of attention for article published in Journal of Medical Case Reports, December 2017
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Title
Gamma-aminobutyric acid-B limbic encephalitis and asystolic cardiac arrest: a case report
Published in
Journal of Medical Case Reports, December 2017
DOI 10.1186/s13256-017-1520-z
Pubmed ID
Authors

Christopher A. Ovens, Angelo Jayamanne, Andrew Duggins

Abstract

Gamma-aminobutyric acid-B receptor autoantibodies are becoming an increasingly recognized contributor to the spectrum of autoimmune limbic encephalitis. They are classically associated with seizures and behavioral disturbance, and may coexist with other autoantibodies. Many are paraneoplastic, most commonly associated with small cell lung cancer. Until now there have been no reports of cardiac dysrhythmias in these patients. A 65-year-old Caucasian man presented with multiple seizures, dysarthria and behavioral disturbance of unclear etiology, with associated asystolic cardiac arrest. Antibody testing showed anti-Gamma-aminobutyric acid-B receptor and anti-Hu antibodies in serum and Gamma-aminobutyric acid-B receptor autoantibodies in cerebrospinal fluid. The diagnosis of small cell lung cancer was subsequently made after lung biopsy, and the patient showed improvement with chemotherapy and intravenous immunoglobulin. We present the case of a patient with Gamma-aminobutyric acid-B receptor limbic encephalitis associated with asystolic cardiac arrest, an association not previously described. This case illustrates how difficult it is to make the diagnosis on clinical grounds alone. We therefore propose more routine antibody testing in patients with similar symptomatology who remain undifferentiated after initial workup. We also recommend that in the acute setting, patients with Gamma-aminobutyric acid-B receptor encephalitis should receive cardiac monitoring, as further research is required to clarify its possible link with cardiac dysrhythmias.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 19%
Other 3 14%
Student > Ph. D. Student 2 10%
Student > Doctoral Student 1 5%
Lecturer 1 5%
Other 2 10%
Unknown 8 38%
Readers by discipline Count As %
Neuroscience 4 19%
Nursing and Health Professions 3 14%
Medicine and Dentistry 3 14%
Social Sciences 1 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Other 0 0%
Unknown 9 43%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2018.
All research outputs
#10,065,010
of 12,582,044 outputs
Outputs from Journal of Medical Case Reports
#1,136
of 2,070 outputs
Outputs of similar age
#203,577
of 272,014 outputs
Outputs of similar age from Journal of Medical Case Reports
#1
of 1 outputs
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