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Exploring the arthritogenicity of Streptococcus dysgalactiae subspecies equisimilis

Overview of attention for article published in BMC Microbiology, February 2018
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Title
Exploring the arthritogenicity of Streptococcus dysgalactiae subspecies equisimilis
Published in
BMC Microbiology, February 2018
DOI 10.1186/s12866-018-1160-5
Pubmed ID
Authors

Oddvar Oppegaard, Haima Mylvaganam, Steinar Skrede, Bård Reiakvam Kittang

Abstract

During the past decades, Streptococcus dysgalactiae subspecies equisimilis (SDSE) has been increasingly recognized as an important human pathogen. Osteoarticular infections is one of the predominant disease manifestations of SDSE, but the pathogenetic rationale for its arthritogenicity has yet to be unravelled. We aimed to explore if the rising incidence of osteoarticular infections caused by this pathogen in our region emanated from clonal expansion of strains with enhanced tropism for bone and joint tissue components or orthopaedic implants. Twenty-nine SDSE-isolates associated with osteoarticular infections were retrospectively identified. Their genomic content and affinity for fibronectin, collagen and stainless steel were compared to 24 temporally and geographically matched SDSE blood culture isolates obtained from patients without bone or joint infections. Despite a thorough genetic and phenotypic dissection, neither the presence or absence of any single gene, nor the binding abilities of the SDSE isolates, were predictive of clinical entity. SNP analysis revealed a heterogenous population, and a correlation between phylogenetic relationships and disease manifestation was not evident. However, we identified a strong concordance between phenotypic binding abilities and genetic variations in the pilus-region, also denoted as the FCT-region (Fibronectin binding, Collagen binding and T-antigen). This observation could be related to the ample and varied repertoire of putative adhesins residing within this region, including proteins predicted to adhere to fibronectin and collagen, as well as fibrinogen. SDSE strains associated with osteoarticular infections do not emanate from subpopulation characterized by distinct genetic or phenotypic traits. The genetic architecture of the pilus region was predictive of the adhesive properties of the SDSE-isolates, but its role in tissue tropism needs further investigation. To the best of our knowledge, this is the first comprehensive characterization of the genetic landscape of the SDSE pilus region.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 21%
Unspecified 1 5%
Student > Master 1 5%
Student > Doctoral Student 1 5%
Professor > Associate Professor 1 5%
Other 1 5%
Unknown 10 53%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 16%
Immunology and Microbiology 3 16%
Medicine and Dentistry 2 11%
Unspecified 1 5%
Unknown 10 53%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2018.
All research outputs
#17,932,482
of 23,025,074 outputs
Outputs from BMC Microbiology
#2,026
of 3,213 outputs
Outputs of similar age
#240,068
of 330,058 outputs
Outputs of similar age from BMC Microbiology
#18
of 25 outputs
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