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Mendeley readers
| Title |
Genetical genomic determinants of alcohol consumption in rats and humans
|
|---|---|
| Published in |
BMC Biology, October 2009
|
| DOI | 10.1186/1741-7007-7-70 |
| Pubmed ID | |
| Authors |
Boris Tabakoff, Laura Saba, Morton Printz, Pam Flodman, Colin Hodgkinson, David Goldman, George Koob, Heather N Richardson, Katerina Kechris, Richard L Bell, Norbert Hübner, Matthias Heinig, Michal Pravenec, Jonathan Mangion, Lucie Legault, Maurice Dongier, Katherine M Conigrave, John B Whitfield, John Saunders, Bridget Grant, Paula L Hoffman, WHO/ISBRA Study on State and Trait Markers of Alcoholism |
| Abstract |
We have used a genetical genomic approach, in conjunction with phenotypic analysis of alcohol consumption, to identify candidate genes that predispose to varying levels of alcohol intake by HXB/BXH recombinant inbred rat strains. In addition, in two populations of humans, we assessed genetic polymorphisms associated with alcohol consumption using a custom genotyping array for 1,350 single nucleotide polymorphisms (SNPs). Our goal was to ascertain whether our approach, which relies on statistical and informatics techniques, and non-human animal models of alcohol drinking behavior, could inform interpretation of genetic association studies with human populations. |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 3% |
| United States | 1 | 1% |
| Spain | 1 | 1% |
| Unknown | 73 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 22% |
| Student > Ph. D. Student | 16 | 21% |
| Student > Bachelor | 7 | 9% |
| Professor > Associate Professor | 7 | 9% |
| Student > Master | 7 | 9% |
| Other | 13 | 17% |
| Unknown | 10 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 30% |
| Medicine and Dentistry | 10 | 13% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Neuroscience | 6 | 8% |
| Psychology | 5 | 6% |
| Other | 9 | 12% |
| Unknown | 17 | 22% |