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Mendeley readers
Attention Score in Context
| Title |
HIV-1 Vif, APOBEC, and Intrinsic Immunity
|
|---|---|
| Published in |
Retrovirology, June 2008
|
| DOI | 10.1186/1742-4690-5-51 |
| Pubmed ID | |
| Authors |
Ritu Goila-Gaur, Klaus Strebel |
| Abstract |
Members of the APOBEC family of cellular cytidine deaminases represent a recently identified group of proteins that provide immunity to infection by retroviruses and protect the cell from endogenous mobile retroelements. Yet, HIV-1 is largely immune to the intrinsic antiviral effects of APOBEC proteins because it encodes Vif (viral infectivity factor), an accessory protein that is critical for in vivo replication of HIV-1. In the absence of Vif, APOBEC proteins are encapsidated by budding virus particles and either cause extensive cytidine to uridine editing of negative sense single-stranded DNA during reverse transcription or restrict virus replication through deaminase-independent mechanisms. Thus, the primary function of Vif is to prevent encapsidation of APOBEC proteins into viral particles. This is in part accomplished by the ability of Vif to induce the ubiquitin-dependent degradation of some of the APOBEC proteins. However, Vif is also able to prevent encapsidation of APOBEC3G and APOBEC3F through degradation-independent mechanism(s). The goal of this review is to recapitulate current knowledge of the functional interaction of HIV-1 and its Vif protein with the APOBEC3 subfamily of proteins and to summarize our present understanding of the mechanism of APOBEC3-dependent retrovirus restriction. |
Mendeley readers
The data shown below were compiled from readership statistics for 281 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 2% |
| Brazil | 4 | 1% |
| Portugal | 3 | 1% |
| United Kingdom | 2 | <1% |
| France | 1 | <1% |
| Hong Kong | 1 | <1% |
| South Africa | 1 | <1% |
| Netherlands | 1 | <1% |
| Canada | 1 | <1% |
| Other | 3 | 1% |
| Unknown | 257 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 70 | 25% |
| Researcher | 48 | 17% |
| Student > Bachelor | 38 | 14% |
| Student > Master | 30 | 11% |
| Professor > Associate Professor | 15 | 5% |
| Other | 42 | 15% |
| Unknown | 38 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 111 | 40% |
| Biochemistry, Genetics and Molecular Biology | 47 | 17% |
| Medicine and Dentistry | 29 | 10% |
| Immunology and Microbiology | 23 | 8% |
| Chemistry | 9 | 3% |
| Other | 20 | 7% |
| Unknown | 42 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2021.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from Retrovirology
#455
of 1,273 outputs
Outputs of similar age
#33,628
of 96,007 outputs
Outputs of similar age from Retrovirology
#5
of 9 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,273 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,007 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.