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Age and sex differences in kidney microRNA expression during the life span of F344 rats

Overview of attention for article published in Biology of Sex Differences, January 2015
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Title
Age and sex differences in kidney microRNA expression during the life span of F344 rats
Published in
Biology of Sex Differences, January 2015
DOI 10.1186/s13293-014-0019-1
Pubmed ID
Authors

Joshua C Kwekel, Vikrant Vijay, Varsha G Desai, Carrie L Moland, James C Fuscoe

Abstract

Growing evidence suggests that epigenetic mechanisms of gene regulation may play a role in susceptibilities to specific toxicities and adverse drug reactions. MiRNAs in particular have been shown to be important regulators in cancer and other diseases and show promise as predictive biomarkers for diagnosis and prognosis. In this study, we characterized the global kidney miRNA expression profile in untreated male and female F344 rats throughout the life span. These findings were correlated with sex-specific susceptibilities to adverse renal events, such as male-biased renal fibrosis and inflammation in old age.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 23%
Student > Ph. D. Student 4 13%
Student > Master 3 10%
Professor > Associate Professor 2 7%
Student > Doctoral Student 2 7%
Other 4 13%
Unknown 8 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 23%
Medicine and Dentistry 6 20%
Biochemistry, Genetics and Molecular Biology 4 13%
Veterinary Science and Veterinary Medicine 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 1 3%
Unknown 10 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2015.
All research outputs
#17,744,232
of 22,786,691 outputs
Outputs from Biology of Sex Differences
#400
of 472 outputs
Outputs of similar age
#242,484
of 352,990 outputs
Outputs of similar age from Biology of Sex Differences
#5
of 6 outputs
Altmetric has tracked 22,786,691 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 472 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.8. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,990 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.