Recently, @dagmareh showed that blocking proteolysis at this site makes HTT a better substrate for autophagy & repairs the autophagy pathway overall. https://t.co/oOP0ijXfcB
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Looking forward to reading this. When @dagmareh & I did this in Huntington disease mice, we saw that the disease causing protein was significantly reduced in their brains after 1 week. But mice eat what you give them. So more research is needed. http
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RT @biorxiv_pubd: Feeding Schedule And Proteolysis Regulate Autophagic Clearance Of Mutant Huntingtin published as: https://t.co/LsxjB7aeS4…