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4️⃣ Anophthalmia Anophthalmia / Microphthalmia 30/100k births. Isolated or syndrome Genetic: SOX2 is major monogenetic culprit. Loss-of-function mutation in 10-20% In-utero infxn: rubella, toxo, varicella, CMV Exposure: ⬇️Vit A, thalidomide, warfarin h