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Network-specific sex differentiation of intrinsic brain function in males with autism

Overview of attention for article published in Molecular Autism, March 2018
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

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2 news outlets
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61 X users
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54 Dimensions

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147 Mendeley
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Title
Network-specific sex differentiation of intrinsic brain function in males with autism
Published in
Molecular Autism, March 2018
DOI 10.1186/s13229-018-0192-x
Pubmed ID
Authors

Dorothea L. Floris, Meng-Chuan Lai, Tanmay Nath, Michael P. Milham, Adriana Di Martino

Abstract

The male predominance in the prevalence of autism spectrum disorder (ASD) has motivated research on sex differentiation in ASD. Multiple sources of evidence have suggested a neurophenotypic convergence of ASD-related characteristics and typical sex differences. Two existing, albeit competing, models provide predictions on such neurophenotypic convergence. These two models are testable with neuroimaging. Specifically, the Extreme Male Brain (EMB) model predicts that ASD is associated with enhanced brain maleness in both males and females with ASD (i.e., a shift-towards-maleness). In contrast, the Gender Incoherence (GI) model predicts a shift-towards-maleness in females, yet a shift-towards-femaleness in males with ASD. To clarify whether either model applies to the intrinsic functional properties of the brain in males with ASD, we measured the statistical overlap between typical sex differences and ASD-related atypicalities in resting-state fMRI (R-fMRI) datasets largely available in males. Main analyses focused on two large-scale R-fMRI samples: 357 neurotypical (NT) males and 471 NT females from the 1000 Functional Connectome Project and 360 males with ASD and 403 NT males from the Autism Brain Imaging Data Exchange. Across all R-fMRI metrics, results revealed coexisting, but network-specific, shift-towards-maleness and shift-towards-femaleness in males with ASD. A shift-towards-maleness mostly involved the default network, while a shift-towards-femaleness mostly occurred in the somatomotor network. Explorations of the associated cognitive processes using available cognitive ontology maps indicated that higher-order social cognitive functions corresponded to the shift-towards-maleness, while lower-order sensory motor processes corresponded to the shift-towards-femaleness. The present findings suggest that atypical intrinsic brain properties in males with ASD partly reflect mechanisms involved in sexual differentiation. A model based on network-dependent atypical sex mosaicism can synthesize prior competing theories on factors involved in sex differentiation in ASD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 61 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 147 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 16%
Researcher 20 14%
Student > Bachelor 20 14%
Student > Master 19 13%
Student > Postgraduate 8 5%
Other 21 14%
Unknown 36 24%
Readers by discipline Count As %
Psychology 37 25%
Neuroscience 29 20%
Biochemistry, Genetics and Molecular Biology 10 7%
Medicine and Dentistry 8 5%
Engineering 4 3%
Other 18 12%
Unknown 41 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 61. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2019.
All research outputs
#687,328
of 25,199,243 outputs
Outputs from Molecular Autism
#64
of 716 outputs
Outputs of similar age
#15,708
of 338,095 outputs
Outputs of similar age from Molecular Autism
#6
of 26 outputs
Altmetric has tracked 25,199,243 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 716 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.1. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,095 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.