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A need for NAD+ in muscle development, homeostasis, and aging

Overview of attention for article published in Skeletal Muscle, March 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#42 of 325)
  • High Attention Score compared to outputs of the same age (84th percentile)

Mentioned by

twitter
26 tweeters
video
2 video uploaders

Citations

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24 Dimensions

Readers on

mendeley
85 Mendeley
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Title
A need for NAD+ in muscle development, homeostasis, and aging
Published in
Skeletal Muscle, March 2018
DOI 10.1186/s13395-018-0154-1
Pubmed ID
Authors

Michelle F. Goody, Clarissa A. Henry

Abstract

Skeletal muscle enables posture, breathing, and locomotion. Skeletal muscle also impacts systemic processes such as metabolism, thermoregulation, and immunity. Skeletal muscle is energetically expensive and is a major consumer of glucose and fatty acids. Metabolism of fatty acids and glucose requires NAD+ function as a hydrogen/electron transfer molecule. Therefore, NAD+ plays a vital role in energy production. In addition, NAD+ also functions as a cosubstrate for post-translational modifications such as deacetylation and ADP-ribosylation. Therefore, NAD+ levels influence a myriad of cellular processes including mitochondrial biogenesis, transcription, and organization of the extracellular matrix. Clearly, NAD+ is a major player in skeletal muscle development, regeneration, aging, and disease. The vast majority of studies indicate that lower NAD+ levels are deleterious for muscle health and higher NAD+ levels augment muscle health. However, the downstream mechanisms of NAD+ function throughout different cellular compartments are not well understood. The purpose of this review is to highlight recent studies investigating NAD+ function in muscle development, homeostasis, disease, and regeneration. Emerging research areas include elucidating roles for NAD+ in muscle lysosome function and calcium mobilization, mechanisms controlling fluctuations in NAD+ levels during muscle development and regeneration, and interactions between targets of NAD+ signaling (especially mitochondria and the extracellular matrix). This knowledge should facilitate identification of more precise pharmacological and activity-based interventions to raise NAD+ levels in skeletal muscle, thereby promoting human health and function in normal and disease states.

Twitter Demographics

The data shown below were collected from the profiles of 26 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 85 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 22%
Student > Master 14 16%
Student > Bachelor 11 13%
Researcher 11 13%
Other 4 5%
Other 11 13%
Unknown 15 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 27 32%
Medicine and Dentistry 10 12%
Agricultural and Biological Sciences 10 12%
Neuroscience 5 6%
Nursing and Health Professions 3 4%
Other 10 12%
Unknown 20 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2021.
All research outputs
#1,790,588
of 18,374,253 outputs
Outputs from Skeletal Muscle
#42
of 325 outputs
Outputs of similar age
#45,327
of 288,459 outputs
Outputs of similar age from Skeletal Muscle
#1
of 1 outputs
Altmetric has tracked 18,374,253 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 325 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,459 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them