Title |
Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany
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Published in |
Journal of Negative Results in BioMedicine, November 2008
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DOI | 10.1186/1477-5751-7-9 |
Pubmed ID | |
Authors |
Qumar Parwez, Susanne Stemmler, Jörg T Epplen, Sabine Hoffjan |
Abstract |
Atopic dermatitis (AD) is believed to result from complex interactions between genetic and environmental factors. A main feature of AD as well as other allergic disorders is serum and tissue eosinophilia. Human eosinophils contain high amounts of cationic granule proteins, including eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), eosinophil peroxidase (EPO) and major basic protein (MBP). Recently, variation in genes encoding eosinophil granule proteins has been suggested to play a role in the pathogenesis of allergic disorders. We therefore genotyped selected single nucleotide polymorphisms within the ECP, EDN, EPO and MBP genes in a cohort of 361 German AD patients and 325 healthy controls. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 30% |
Student > Master | 3 | 30% |
Student > Postgraduate | 2 | 20% |
Other | 1 | 10% |
Unknown | 1 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 30% |
Agricultural and Biological Sciences | 3 | 30% |
Mathematics | 1 | 10% |
Nursing and Health Professions | 1 | 10% |
Unknown | 2 | 20% |