Title |
Differential epithelial expression of the putative innate immune molecule SPLUNC1 in Cystic Fibrosis
|
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Published in |
Respiratory Research, November 2007
|
DOI | 10.1186/1465-9921-8-79 |
Pubmed ID | |
Authors |
Lynne Bingle, Frances A Barnes, Simon S Cross, Doris Rassl, William A Wallace, Michael A Campos, Colin D Bingle |
Abstract |
Short PLUNC1 (SPLUNC1) is the founding member of a family of proteins (PLUNCS) expressed in the upper respiratory tract and oral cavity, which may function in host defence. It is one of the most highly expressed genes in the upper airways and the protein has been detected in sputum and nasal secretions. The biology of the PLUNC family is poorly understood but in keeping with the putative function of the protein as an immune defence protein, a number of RNA and protein studies have indicated that SPLUNC1 is increased in inflammatory/infectious conditions such as Cystic Fibrosis (CF), COPD and allergic rhinitis. |
Mendeley readers
Geographical breakdown
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Unknown | 39 | 95% |
Demographic breakdown
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Other | 5 | 12% |
Researcher | 5 | 12% |
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Other | 9 | 22% |
Unknown | 6 | 15% |
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Neuroscience | 1 | 2% |
Other | 1 | 2% |
Unknown | 6 | 15% |