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Differential cyclooxygenase expression levels and survival associations in type I and type II ovarian tumors

Overview of attention for article published in Journal of Ovarian Research, February 2018
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)

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2 tweeters

Citations

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14 Dimensions

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8 Mendeley
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Title
Differential cyclooxygenase expression levels and survival associations in type I and type II ovarian tumors
Published in
Journal of Ovarian Research, February 2018
DOI 10.1186/s13048-018-0389-9
Pubmed ID
Authors

Alicia Beeghly-Fadiel, Andrew J. Wilson, Spencer Keene, Meral El Ramahi, Shu Xu, Lawrence J. Marnett, Oluwole Fadare, Marta A. Crispens, Dineo Khabele

Abstract

High cyclooxygenase (COX)-2 expression in ovarian tumors has been associated with poor prognosis, but the role of COX-1 expression and its relation to survival is less clear. Here, we evaluated COX expression and associations with survival outcomes between type I (clear cell, mucinous, low grade endometrioid and low grade serous) and type II (high grade serous and high grade endometrioid) ovarian tumors. We developed and validated a new COX-1 antibody, and conducted immunohistochemical (IHC) staining for COX-1 and COX-2 on a tissue microarray (TMA) of 190 primary ovarian tumors. In addition to standard IHC scoring and H-scores to combine the percentage of positive cells and staining intensity, we also measured COX-1 and COX-2 mRNA expression by QPCR. High expression was defined as greater than or equal to median values. Clinical characteristics and disease outcomes were ascertained from medical records. Associations with disease-free survival (DFS) and overall survival (OS) were quantified by hazard ratios (HRs) and confidence intervals (CIs) from proportional hazards regression. Type I tumors had high COX-2 expression, while type II tumors had high COX-1 expression. In multivariable adjusted regression models, higher COX-1 mRNA expression was associated with shorter DFS (HR: 6.37, 95% CI: 1.84-22.01) and OS (HR: 2.26, 95% CI: 1.04-4.91), while higher H-scores for COX-2 expression were associated with shorter DFS (HR: 1.92, 95% CI: 1.06-3.49). Stratified analysis indicated that COX-2 was significantly associated with DFS among cases with Type II tumors (HR: 1.93, 95% CI: 1.06-3.53). These findings suggest that ovarian tumor type contributes to differences in COX expression levels and associations with survival.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 1 13%
Student > Doctoral Student 1 13%
Student > Bachelor 1 13%
Student > Master 1 13%
Researcher 1 13%
Other 1 13%
Unknown 2 25%
Readers by discipline Count As %
Unspecified 1 13%
Pharmacology, Toxicology and Pharmaceutical Science 1 13%
Nursing and Health Professions 1 13%
Business, Management and Accounting 1 13%
Medicine and Dentistry 1 13%
Other 0 0%
Unknown 3 38%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2018.
All research outputs
#7,007,723
of 12,622,988 outputs
Outputs from Journal of Ovarian Research
#69
of 245 outputs
Outputs of similar age
#128,472
of 273,606 outputs
Outputs of similar age from Journal of Ovarian Research
#1
of 1 outputs
Altmetric has tracked 12,622,988 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 245 research outputs from this source. They receive a mean Attention Score of 3.1. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,606 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them