Title |
Cytokine-associated neutrophil extracellular traps and antinuclear antibodies in Plasmodium falciparum infected children under six years of age
|
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Published in |
Malaria Journal, February 2008
|
DOI | 10.1186/1475-2875-7-41 |
Pubmed ID | |
Authors |
Virginia S Baker, Godwin E Imade, Norman B Molta, Pallavi Tawde, Sunday D Pam, Michael O Obadofin, Soloman A Sagay, Daniel Z Egah, Daniel Iya, Bangmboye B Afolabi, Murray Baker, Karen Ford, Robert Ford, Kenneth H Roux, Thomas CS Keller |
Abstract |
In Plasmodium falciparum-infected children, the relationships between blood cell histopathology, blood plasma components, development of immunocompetence and disease severity remain poorly understood. Blood from Nigerian children with uncomplicated malaria was analysed to gain insight into these relationships. This investigation presents evidence for circulating neutrophil extracellular traps (NETs) and antinuclear IgG antibodies (ANA). The presence of NETs and ANA to double-stranded DNA along with the cytokine profiles found suggests autoimmune mechanisms that could produce pathogenesis in children, but immunoprotection in adults. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | <1% |
Italy | 1 | <1% |
Brazil | 1 | <1% |
India | 1 | <1% |
Denmark | 1 | <1% |
Nigeria | 1 | <1% |
Spain | 1 | <1% |
Unknown | 143 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 39 | 26% |
Student > Master | 24 | 16% |
Researcher | 23 | 15% |
Student > Bachelor | 15 | 10% |
Professor | 7 | 5% |
Other | 19 | 13% |
Unknown | 23 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 41 | 27% |
Medicine and Dentistry | 27 | 18% |
Immunology and Microbiology | 26 | 17% |
Biochemistry, Genetics and Molecular Biology | 14 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Other | 6 | 4% |
Unknown | 33 | 22% |