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Cerebrospinal fluid-stem cell interactions may pave the path for cell-based therapy in neurological diseases

Overview of attention for article published in Stem Cell Research & Therapy, March 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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8 X users
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1 Facebook page

Citations

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18 Dimensions

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46 Mendeley
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Title
Cerebrospinal fluid-stem cell interactions may pave the path for cell-based therapy in neurological diseases
Published in
Stem Cell Research & Therapy, March 2018
DOI 10.1186/s13287-018-0807-3
Pubmed ID
Authors

Chao Ren, Peiyuan Yin, Neng Ren, Zhe Wang, Jiahui Wang, Caiyi Zhang, Wei Ge, Deqin Geng, Xiaotong Wang

Abstract

Recent studies have suggested that the regulation of endogenous neural stem cells (NSCs) or transplanting of exogenous nerve cells are the newest and most promising methods for the treatment of dementia and other neurological diseases. The special location and limited number of endogenous NSCs, however, restrict their clinical application. The success in directional differentiation of exogenous stem cells from other tissue sources into neural cells has provided a novel source for NSCs. Study on the relative mechanisms is still at the preliminary stage. Currently the induction methods include: 1) cell growth factor induction; 2) chemical induction; 3) combined growth factor-chemical induction; or 4) other induction methods such as traumatic brain tissue homogenate, gene transfection, traditional Chinese medicine, and coculture induction. Cerebrospinal fluid (CSF), as a natural medium under physiological conditions, contains a variety of progrowth peptide factors that can promote the proliferation and differentiation of mesenchymal stromal cells (MSCs) into neural cells through the corresponding receptors on the cell surface. This suggests that CSF can not only nourish the nerve cells, but also become an effective and suitable inducer to increase the yield of NSCs. However, some other studies believed that CSF contained certain inhibitory components against the differentiation of primary stem cells into mature neural cells. Based on the above background, here we review the relative literature on the influence of the CSF on stem cells in order to provide a more comprehensive reference for the wide clinical application of NSCs in the future.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 17%
Student > Ph. D. Student 7 15%
Student > Bachelor 6 13%
Researcher 5 11%
Librarian 1 2%
Other 3 7%
Unknown 16 35%
Readers by discipline Count As %
Medicine and Dentistry 6 13%
Agricultural and Biological Sciences 5 11%
Biochemistry, Genetics and Molecular Biology 5 11%
Neuroscience 5 11%
Engineering 3 7%
Other 5 11%
Unknown 17 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2019.
All research outputs
#6,871,331
of 23,026,672 outputs
Outputs from Stem Cell Research & Therapy
#657
of 2,429 outputs
Outputs of similar age
#120,372
of 332,332 outputs
Outputs of similar age from Stem Cell Research & Therapy
#21
of 66 outputs
Altmetric has tracked 23,026,672 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 2,429 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,332 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.