Title |
|
---|---|
Published in |
Cancer Cell International, January 2005
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DOI | 10.1186/1475-2867-5-30 |
Pubmed ID | |
Authors |
Cheol-Hee Choi |
Abstract |
One of the major problems related with anticancer chemotherapy is resistance against anticancer drugs. The ATP-binding cassette (ABC) transporters are a family of transporter proteins that are responsible for drug resistance and a low bioavailability of drugs by pumping a variety of drugs out cells at the expense of ATP hydrolysis. One strategy for reversal of the resistance of tumor cells expressing ABC transporters is combined use of anticancer drugs with chemosensitizers. In this review, the physiological functions and structures of ABC transporters, and the development of chemosensitizers are described focusing on well-known proteins including P-glycoprotein, multidrug resistance associated protein, and breast cancer resistance protein. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | <1% |
Switzerland | 1 | <1% |
South Africa | 1 | <1% |
India | 1 | <1% |
United Kingdom | 1 | <1% |
Mexico | 1 | <1% |
Argentina | 1 | <1% |
Belgium | 1 | <1% |
Unknown | 399 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 87 | 21% |
Student > Bachelor | 68 | 17% |
Student > Master | 57 | 14% |
Researcher | 31 | 8% |
Student > Doctoral Student | 26 | 6% |
Other | 44 | 11% |
Unknown | 94 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 113 | 28% |
Agricultural and Biological Sciences | 79 | 19% |
Medicine and Dentistry | 35 | 9% |
Chemistry | 27 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 21 | 5% |
Other | 26 | 6% |
Unknown | 106 | 26% |