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Public health impact and cost effectiveness of routine childhood vaccination for hepatitis a in Jordan: a dynamic model approach

Overview of attention for article published in BMC Infectious Diseases, March 2018
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Title
Public health impact and cost effectiveness of routine childhood vaccination for hepatitis a in Jordan: a dynamic model approach
Published in
BMC Infectious Diseases, March 2018
DOI 10.1186/s12879-018-3034-8
Pubmed ID
Authors

Wail A. Hayajneh, Vincent J. Daniels, Cerise K. James, Muhammet Nabi Kanıbir, Matthew Pilsbury, Morgan Marks, Michelle G. Goveia, Elamin H. Elbasha, Erik Dasbach, Camilo J. Acosta

Abstract

As the socioeconomic conditions in Jordan have improved over recent decades the disease and economic burden of Hepatitis A has increased. The purpose of this study is to assess the potential health and economic impact of a two-dose hepatitis A vaccine program covering one-year old children in Jordan. We adapted an age-structured population model of hepatitis A transmission dynamics to project the epidemiologic and economic impact of vaccinating one-year old children for 50 years in Jordan. The epidemiologic model was calibrated using local data on hepatitis A in Jordan. These data included seroprevalence and incidence data from the Jordan Ministry of Health as well as hospitalization data from King Abdullah University Hospital in Irbid, Jordan. We assumed 90% of all children would be vaccinated with the two-dose regimen by two years of age. The economic evaluation adopted a societal perspective and measured benefits using the quality-adjusted life-year (QALY). The modeled vaccination program reduced the incidence of hepatitis A in Jordan by 99%, 50 years after its introduction. The model projected 4.26 million avoided hepatitis A infections, 1.42 million outpatient visits, 22,475 hospitalizations, 508 fulminant cases, 95 liver transplants, and 76 deaths over a 50 year time horizon. In addition, we found, over a 50 year time horizon, the vaccination program would gain 37,502 QALYs and save over $42.6 million in total costs. The vaccination program became cost-saving within 6 years of its introduction and was highly cost-effective during the first 5 years. A vaccination program covering one-year old children is projected to be a cost-saving intervention that will significantly reduce the public health and economic burden of hepatitis A in Jordan.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 18%
Researcher 6 15%
Student > Ph. D. Student 5 13%
Student > Bachelor 5 13%
Student > Doctoral Student 3 8%
Other 3 8%
Unknown 10 26%
Readers by discipline Count As %
Medicine and Dentistry 10 26%
Pharmacology, Toxicology and Pharmaceutical Science 4 10%
Nursing and Health Professions 3 8%
Biochemistry, Genetics and Molecular Biology 2 5%
Environmental Science 1 3%
Other 7 18%
Unknown 12 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2018.
All research outputs
#11,245,615
of 12,633,553 outputs
Outputs from BMC Infectious Diseases
#4,017
of 4,700 outputs
Outputs of similar age
#237,869
of 274,054 outputs
Outputs of similar age from BMC Infectious Diseases
#1
of 1 outputs
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