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Plasma anandamide concentrations are lower in children with autism spectrum disorder

Overview of attention for article published in Molecular Autism, March 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
55 tweeters
facebook
10 Facebook pages

Citations

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48 Dimensions

Readers on

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108 Mendeley
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Title
Plasma anandamide concentrations are lower in children with autism spectrum disorder
Published in
Molecular Autism, March 2018
DOI 10.1186/s13229-018-0203-y
Pubmed ID
Authors

Debra S. Karhson, Karolina M. Krasinska, Jamie Ahloy Dallaire, Robin A. Libove, Jennifer M. Phillips, Allis S. Chien, Joseph P. Garner, Antonio Y. Hardan, Karen J. Parker

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted, stereotyped behaviors and impairments in social communication. Although the underlying biological mechanisms of ASD remain poorly understood, recent preclinical research has implicated the endogenous cannabinoid (or endocannabinoid), anandamide, as a significant neuromodulator in rodent models of ASD. Despite this promising preclinical evidence, no clinical studies to date have tested whether endocannabinoids are dysregulated in individuals with ASD. Here, we addressed this critical gap in knowledge by optimizing liquid chromatography-tandem mass spectrometry methodology to quantitatively analyze anandamide concentrations in banked blood samples collected from a cohort of children with and without ASD (N = 112). Anandamide concentrations significantly differentiated ASD cases (N = 59) from controls (N = 53), such that children with lower anandamide concentrations were more likely to have ASD (p = 0.041). In keeping with this notion, anandamide concentrations were also significantly lower in ASD compared to control children (p = 0.034). These findings are the first empirical human data to translate preclinical rodent findings to confirm a link between plasma anandamide concentrations in children with ASD. Although preliminary, these data suggest that impaired anandamide signaling may be involved in the pathophysiology of ASD.

Twitter Demographics

The data shown below were collected from the profiles of 55 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 108 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 18%
Student > Master 15 14%
Student > Bachelor 15 14%
Student > Ph. D. Student 9 8%
Professor > Associate Professor 6 6%
Other 22 20%
Unknown 22 20%
Readers by discipline Count As %
Medicine and Dentistry 18 17%
Neuroscience 16 15%
Psychology 13 12%
Biochemistry, Genetics and Molecular Biology 9 8%
Agricultural and Biological Sciences 8 7%
Other 13 12%
Unknown 31 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 56. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2020.
All research outputs
#498,713
of 18,681,452 outputs
Outputs from Molecular Autism
#58
of 604 outputs
Outputs of similar age
#14,525
of 289,480 outputs
Outputs of similar age from Molecular Autism
#1
of 1 outputs
Altmetric has tracked 18,681,452 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 604 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,480 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them