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Function of aquaporins in sepsis: a systematic review

Overview of attention for article published in Cell & Bioscience, February 2018
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63 Mendeley
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Title
Function of aquaporins in sepsis: a systematic review
Published in
Cell & Bioscience, February 2018
DOI 10.1186/s13578-018-0211-9
Pubmed ID
Authors

Katharina Rump, Michael Adamzik

Abstract

Sepsis is a common cause of death in intensive care units worldwide. Due to the high complexity of this immunological syndrome development of novel therapeutic strategies is urgent. Promising drug targets or biomarkers may depict aquaporins (AQPs) as they regulate crucial key mechanisms of sepsis. Here we report on base of the current literature that several AQPs are involved in different physiological processes of sepsis. In immune system mainly AQPs 3, 5 and 9 seem to be important, as they regulate the migration of different immune cells. Several studies showed that AQP3 is essential for T cell function and macrophage migration and that AQP5 and AQP9 regulate neutrophil cell migration and impact sepsis survival. Additionally, to the function in immune system AQPs 1 and 5 play a role in sepsis induced lung injury and their downregulation after inflammatory stimuli impair lung injury. By contrast, AQP4 expression is up-regulated during brain inflammation and aggravates brain edema in sepsis. In kidney AQP2 expression is downregulated during sepsis and can cause renal failure. Some studies also suggest a role of AQP1 in cardiac function. In conclusion, AQPs are involved in many physiological dysfunctions in sepsis and their expressions are differently regulated. Additional research on the regulatory mechanisms of aquaporins may identify potential therapeutic targets.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 63 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 13%
Researcher 6 10%
Student > Ph. D. Student 6 10%
Student > Doctoral Student 4 6%
Student > Bachelor 3 5%
Other 12 19%
Unknown 24 38%
Readers by discipline Count As %
Medicine and Dentistry 18 29%
Neuroscience 4 6%
Biochemistry, Genetics and Molecular Biology 4 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Immunology and Microbiology 3 5%
Other 7 11%
Unknown 24 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2018.
All research outputs
#18,590,133
of 23,026,672 outputs
Outputs from Cell & Bioscience
#580
of 946 outputs
Outputs of similar age
#331,988
of 442,609 outputs
Outputs of similar age from Cell & Bioscience
#4
of 11 outputs
Altmetric has tracked 23,026,672 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 946 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,609 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.