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Triaging informative cis-regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development

Overview of attention for article published in Parasites & Vectors, February 2015
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  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

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4 tweeters

Citations

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9 Dimensions

Readers on

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27 Mendeley
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Title
Triaging informative cis-regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development
Published in
Parasites & Vectors, February 2015
DOI 10.1186/s13071-015-0701-0
Pubmed ID
Authors

Karen Russell, Richard Emes, Paul Horrocks

Abstract

BackgroundOver 2700 genes are subject to stage-specific regulation during the intraerythrocytic development of the human malaria parasite Plasmodium falciparum. Bioinformatic analyses have identified a large number of over-represented motifs in the 5¿ flanking regions of these genes that may act as cis-acting factors in the promoter-based control of temporal expression. Triaging these lists to provide candidates most likely to play a role in regulating temporal expression is challenging, but important if we are to effectively design in vitro studies to validate this role.MethodsWe report here the application of a repeated search of variations of 5¿ flanking sequences from P. falciparum using the Finding Informative Regulatory Elements (FIRE) algorithm.ResultsOur approach repeatedly found a short-list of high scoring DNA motifs, for which cognate specific transcription factors were available, that appear to be typically associated with upregulation of mRNA accumulation during the first half of intraerythrocytic development.ConclusionsWe propose these cis-trans interactions may provide a combinatorial promoter-based control of gene expression to complement more global mechanisms of gene regulation that can account for temporal control during the second half of intraerythrocytic development.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 26%
Student > Master 5 19%
Researcher 4 15%
Professor 3 11%
Student > Doctoral Student 2 7%
Other 4 15%
Unknown 2 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 37%
Biochemistry, Genetics and Molecular Biology 6 22%
Medicine and Dentistry 4 15%
Immunology and Microbiology 2 7%
Computer Science 1 4%
Other 0 0%
Unknown 4 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2016.
All research outputs
#2,402,565
of 6,920,439 outputs
Outputs from Parasites & Vectors
#503
of 1,875 outputs
Outputs of similar age
#67,926
of 230,629 outputs
Outputs of similar age from Parasites & Vectors
#29
of 101 outputs
Altmetric has tracked 6,920,439 research outputs across all sources so far. This one has received more attention than most of these and is in the 64th percentile.
So far Altmetric has tracked 1,875 research outputs from this source. They receive a mean Attention Score of 3.6. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,629 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.