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The development of salt-sensitive hypertension regulated by PSGL-1 gene in mice

Overview of attention for article published in Cell & Bioscience, March 2018
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Title
The development of salt-sensitive hypertension regulated by PSGL-1 gene in mice
Published in
Cell & Bioscience, March 2018
DOI 10.1186/s13578-018-0218-2
Pubmed ID
Authors

Yuhui Yang, Xue Liu, Yunpeng Liu, Hui Fu, Ying Gao, Xing Liu, Xiaoliang Jiang

Abstract

Chronic inflammatory is involved in the development of salt-sensitive hypertension and other cardiovascular diseases. PSGL-1 plays an important role in the inflammatory response. In this study, we used PSGL-1-/-and PSGL-1+/+mice fed with high salt diet to measure the blood pressure, inflammatory response and vascular injury. We found that, in PSGL-1+/+mice, high salt diet resulted in high blood pressure with the increased expression of serum inflammatory cytokines IL-6, IL-1β and TNFɑ, vascular injury markers MCP-1, ET-1, and VWF, and renal macrophages and T cells infiltration, and endothelium-dependent acetylcholine vasodilation dysfunction. However, the influence was not found in PSGL-1-/-mice. The deficiency of PSGL-1 prevented the increased adhesion of peripheral blood mononuclear cells to endothelial cells by high salt environment. Our results indicate that PSGL-1 is involved in the development of salt-sensitive hypertension via vascular inflammation and injury. The high salt induced inflammation may be initiated by leukocytes and endothelial cells adhesion through PSGL-1 binding with P-selectin or/and E-selectin.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 40%
Student > Doctoral Student 1 20%
Unknown 2 40%
Readers by discipline Count As %
Nursing and Health Professions 2 40%
Medicine and Dentistry 1 20%
Unknown 2 40%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2018.
All research outputs
#11,266,306
of 12,662,564 outputs
Outputs from Cell & Bioscience
#245
of 281 outputs
Outputs of similar age
#238,269
of 274,306 outputs
Outputs of similar age from Cell & Bioscience
#7
of 7 outputs
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So far Altmetric has tracked 281 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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