Title |
Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer
|
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Published in |
Molecular Cancer, July 2010
|
DOI | 10.1186/1476-4598-9-198 |
Pubmed ID | |
Authors |
Jipei Liao, Lei Yu, Yuping Mei, Maria Guarnera, Jun Shen, Ruiyun Li, Zhenqiu Liu, Feng Jiang |
Abstract |
Non-small-cell lung cancer (NSCLC) is the leading cause of cancer death. Early detection of NSCLC will improve its outcome. The current techniques for NSCLC early detection are either invasive or have low accuracy. Molecular analyses of clinical specimens present promising diagnostic approaches. Non-coding RNAs (ncRNAs) play an important role in tumorigenesis and could be developed as biomarkers for cancer. Here we aimed to develop small nucleolar RNAs (snoRNAs), a common class of ncRNAs, as biomarkers for NSCLC early detection. The study comprised three phases: (1) profiling snoRNA signatures in 22 NSCLC tissues and matched noncancerous lung tissues by GeneChip Array, (2) validating expressions of the signatures by RT-qPCR in the tissues, and (3) evaluating plasma expressions of the snoRNAs in 37 NSCLC patients, 26 patients with chronic obstructive pulmonary disease (COPD), and 22 healthy subjects. |
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Netherlands | 2 | 1% |
United States | 2 | 1% |
Italy | 2 | 1% |
Germany | 1 | <1% |
France | 1 | <1% |
United Kingdom | 1 | <1% |
Australia | 1 | <1% |
Unknown | 163 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 43 | 25% |
Student > Ph. D. Student | 40 | 23% |
Student > Master | 17 | 10% |
Student > Bachelor | 12 | 7% |
Student > Postgraduate | 12 | 7% |
Other | 23 | 13% |
Unknown | 26 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 54 | 31% |
Biochemistry, Genetics and Molecular Biology | 45 | 26% |
Medicine and Dentistry | 28 | 16% |
Immunology and Microbiology | 4 | 2% |
Computer Science | 2 | 1% |
Other | 7 | 4% |
Unknown | 33 | 19% |