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MicroRNA signatures differentiate Crohn’s disease from ulcerative colitis

Overview of attention for article published in BMC Immunology, February 2015
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  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

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2 X users
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1 Wikipedia page

Citations

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147 Dimensions

Readers on

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170 Mendeley
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Title
MicroRNA signatures differentiate Crohn’s disease from ulcerative colitis
Published in
BMC Immunology, February 2015
DOI 10.1186/s12865-015-0069-0
Pubmed ID
Authors

Jeremy S Schaefer, Taraq Attumi, Antone R Opekun, Bincy Abraham, Jason Hou, Harold Shelby, David Y Graham, Charles Streckfus, John R Klein

Abstract

Excessive and inappropriate immune responses are the hallmark of several autoimmune disorders, including the inflammatory bowel diseases (IBD): Crohn's disease (CD) and ulcerative colitis (UC). A complex etiology involving both environmental and genetic factors influences IBD pathogenesis. The role of microRNAs (miRNAs), noncoding RNAs involved in regulating numerous biological processes, to IBD pathology, in terms of initiation and progression, remains ill-defined. In the present study, we evaluated the relationship between colon, peripheral blood, and saliva whole miRNome expression in IBD patients and non-inflammatory bowel disease (non-IBD) controls to identify miRNAs that could discriminate CD from UC. Quantitative real-time PCR (qRT-PCR) was used to validate and assess miRNA expression. Microarray analysis demonstrated that upwards of twenty six miRNAs were changed in CD and UC colon biopsies relative to the non-IBD controls. CD was associated with the differential expression of 10 miRNAs while UC was associated with 6 miRNAs in matched colon tissues. CD was associated with altered expression of 6 miRNAs while UC was associated with 9 miRNAs in whole blood. Expression of miR-101 in CD patients and miR-21, miR-31, miR-142-3p, and miR-142-5p in UC patients were altered in saliva. Our results suggest that there is specific miRNA expression patterns associated with UC versus CD in three separate tissue/body fluids (colon, blood, and saliva). Further, the aberrant miRNA expression profiles indicate that miRNAs may be contributory to IBD pathogenesis, or at least reflect the underlying inflammation. Scrutinizing miRNA expression in saliva and blood samples may be beneficial in monitoring or diagnosing disease in IBD patients. A panel of miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-146a, and miR-375) may be used as markers to identify and discriminate between CD and UC.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 170 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Unknown 169 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 21%
Researcher 25 15%
Unspecified 19 11%
Student > Bachelor 15 9%
Student > Master 14 8%
Other 34 20%
Unknown 28 16%
Readers by discipline Count As %
Medicine and Dentistry 39 23%
Agricultural and Biological Sciences 31 18%
Biochemistry, Genetics and Molecular Biology 28 16%
Unspecified 19 11%
Immunology and Microbiology 6 4%
Other 13 8%
Unknown 34 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2022.
All research outputs
#7,042,198
of 24,945,754 outputs
Outputs from BMC Immunology
#116
of 613 outputs
Outputs of similar age
#92,703
of 368,937 outputs
Outputs of similar age from BMC Immunology
#7
of 16 outputs
Altmetric has tracked 24,945,754 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 613 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 368,937 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.