Title |
Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death
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Published in |
Thrombosis Journal, December 2008
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DOI | 10.1186/1477-9560-6-17 |
Pubmed ID | |
Authors |
Yue-Mei Fan, Pekka J Karhunen, Mari Levula, Erkki Ilveskoski, Jussi Mikkelsson, Olli A Kajander, Otso Järvinen, Niku Oksala, Janita Thusberg, Mauno Vihinen, Juha-Pekka Salenius, Leena Kytömäki, Juhani T Soini, Reijo Laaksonen, Terho Lehtimäki |
Abstract |
Disturbed cellular cholesterol homeostasis may lead to accumulation of cholesterol in human atheroma plaques. Cellular cholesterol homeostasis is controlled by the sterol regulatory element-binding transcription factor 2 (SREBF-2) and the SREBF cleavage-activating protein (SCAP). We investigated whole genome expression in a series of human atherosclerotic samples from different vascular territories and studied whether the non-synonymous coding variants in the interacting domains of two genes, SREBF-2 1784G>C (rs2228314) and SCAP 2386A>G, are related to the progression of coronary atherosclerosis and the risk of pre-hospital sudden cardiac death (SCD). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 8% |
Sweden | 1 | 4% |
Unknown | 23 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 23% |
Researcher | 4 | 15% |
Professor | 4 | 15% |
Other | 2 | 8% |
Student > Bachelor | 2 | 8% |
Other | 3 | 12% |
Unknown | 5 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 31% |
Biochemistry, Genetics and Molecular Biology | 6 | 23% |
Agricultural and Biological Sciences | 5 | 19% |
Mathematics | 1 | 4% |
Chemistry | 1 | 4% |
Other | 0 | 0% |
Unknown | 5 | 19% |