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An association study on contrasting cystic fibrosis endophenotypes recognizes KRT8 but not KRT18 as a modifier of cystic fibrosis disease severity and CFTR mediated residual chloride secretion

Overview of attention for article published in BMC Medical Genomics, May 2011
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3 Wikipedia pages

Citations

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14 Dimensions

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Title
An association study on contrasting cystic fibrosis endophenotypes recognizes KRT8 but not KRT18 as a modifier of cystic fibrosis disease severity and CFTR mediated residual chloride secretion
Published in
BMC Medical Genomics, May 2011
DOI 10.1186/1471-2350-12-62
Pubmed ID
Authors

Frauke Stanke, Silke Hedtfeld, Tim Becker, Burkhard Tümmler

Abstract

F508del-CFTR, the most frequent disease-causing mutation among Caucasian cystic fibrosis (CF) patients, has been characterised as a mutant defective in protein folding, processing and trafficking. We have investigated the two neighbouring cytokeratin genes KRT8 and KRT18 in a candidate gene approach to ask whether variants in KRT8 and/or KRT18 modify the impaired ion conductance known as the CF basic defect, and whether they are associated with correct trafficking of mutant CFTR and disease severity of CF.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 4%
Poland 1 4%
Brazil 1 4%
Unknown 24 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 22%
Student > Master 4 15%
Student > Bachelor 3 11%
Student > Ph. D. Student 3 11%
Lecturer > Senior Lecturer 1 4%
Other 3 11%
Unknown 7 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 26%
Biochemistry, Genetics and Molecular Biology 3 11%
Medicine and Dentistry 3 11%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Psychology 2 7%
Other 2 7%
Unknown 8 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2021.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from BMC Medical Genomics
#637
of 2,444 outputs
Outputs of similar age
#45,322
of 121,699 outputs
Outputs of similar age from BMC Medical Genomics
#14
of 26 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,444 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,699 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.