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Association of adiponectin gene variants with idiopathic recurrent miscarriage according to obesity status: a case–control study

Overview of attention for article published in Journal of Translational Medicine, March 2018
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Title
Association of adiponectin gene variants with idiopathic recurrent miscarriage according to obesity status: a case–control study
Published in
Journal of Translational Medicine, March 2018
DOI 10.1186/s12967-018-1453-3
Pubmed ID
Authors

Maryam Dendana, Wael Bahia, Ramzi R. Finan, Mariam Al-Mutawa, Wassim Y. Almawi

Abstract

This study addresses whether the association of adiponectin gene (ADIPOQ) variants with idiopathic recurrent pregnancy loss (RPL) is influenced by obesity. Retrospective case-control study performed in outpatient obstetrics/gynecology clinics. Study subjects comprised 308 women with RPL, defined as ≥ 3 consecutive miscarriages of unknown etiology, and 310 control women. ADIPOQ genotyping was done by allele exclusion method on real-time PCR. Of the 14 ADIPOQ variants tested, the minor allele frequency (MAF) of rs4632532, rs17300539, rs266729, rs182052, rs16861209, and rs7649121 were significantly higher, while rs2241767, and rs1063539 MAF were lower in RPL cases, hence assigning RPL-susceptibility and protection to these variants, respectively. Higher frequencies of heterozygous rs17300539 and rs16861209, and homozygous rs4632532, rs266729, and rs182052 genotypes, and reduced frequencies of heterozygous rs1063539 and rs2241767, homozygous rs2241766 genotypes were seen in RPL cases. ADIPOQ rs4632532, and rs2241766 were associated with RPL in obese, while rs1063539 and rs16861209 were associated with RPL in non-obese women; rs182052 and rs7649121 associated with RPL independently of BMI changes. Based on LD pattern, two haplotype blocks were identified. Within Block 1 containing rs4632532, rs16861194, rs17300539, rs266729, rs182052, rs16861209, rs822396, and rs7649121, increased frequency of CAGGACAT and TAACGAAA, and reduced frequency of TAGCGCAA haplotypes were seen in RPL cases when compared to controls, thereby assigning RPL susceptibility and protection, respectively. This is the first study to document contribution of ADIPOQ variants and haplotypes with RPL, and also to underscore the contribution of obesity to genetic association studies.

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Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 28%
Student > Doctoral Student 4 22%
Researcher 2 11%
Professor 1 6%
Lecturer 1 6%
Other 1 6%
Unknown 4 22%
Readers by discipline Count As %
Medicine and Dentistry 8 44%
Biochemistry, Genetics and Molecular Biology 3 17%
Nursing and Health Professions 1 6%
Immunology and Microbiology 1 6%
Agricultural and Biological Sciences 1 6%
Other 0 0%
Unknown 4 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2021.
All research outputs
#15,510,040
of 20,034,281 outputs
Outputs from Journal of Translational Medicine
#2,587
of 3,505 outputs
Outputs of similar age
#209,765
of 295,660 outputs
Outputs of similar age from Journal of Translational Medicine
#1
of 1 outputs
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