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Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities

Overview of attention for article published in Journal of Experimental & Clinical Cancer Research, March 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

news
1 news outlet
twitter
2 X users
patent
2 patents

Citations

dimensions_citation
145 Dimensions

Readers on

mendeley
321 Mendeley
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Title
Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities
Published in
Journal of Experimental & Clinical Cancer Research, March 2018
DOI 10.1186/s13046-018-0719-1
Pubmed ID
Authors

Manuela Porru, Luca Pompili, Carla Caruso, Annamaria Biroccio, Carlo Leonetti

Abstract

Developing drugs that target KRAS, the most frequently mutated oncogene in cancer, has not been successful despite much concerted efforts dedicated towards it in the last thirty years. Considering the key role this driver oncogene plays, the pharmacological drugging of KRAS remains a key challenge for cancer research. In this review, we highlight the emerging experimental strategies for blocking KRAS function and signaling and its direct targeting. We also report on the results in this field of research produced by our group.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 321 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 321 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 66 21%
Student > Master 47 15%
Student > Ph. D. Student 46 14%
Researcher 25 8%
Student > Doctoral Student 12 4%
Other 28 9%
Unknown 97 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 87 27%
Medicine and Dentistry 50 16%
Pharmacology, Toxicology and Pharmaceutical Science 21 7%
Agricultural and Biological Sciences 20 6%
Immunology and Microbiology 9 3%
Other 24 7%
Unknown 110 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2023.
All research outputs
#2,736,744
of 25,998,826 outputs
Outputs from Journal of Experimental & Clinical Cancer Research
#123
of 2,446 outputs
Outputs of similar age
#56,607
of 355,931 outputs
Outputs of similar age from Journal of Experimental & Clinical Cancer Research
#4
of 44 outputs
Altmetric has tracked 25,998,826 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,446 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 355,931 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.