Title |
Lack of genomic evidence of AI-2 receptors suggests a non-quorum sensing role for luxS in most bacteria
|
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Published in |
BMC Microbiology, September 2008
|
DOI | 10.1186/1471-2180-8-154 |
Pubmed ID | |
Authors |
Fabio Rezzonico, Brion Duffy |
Abstract |
Great excitement accompanied discoveries over the last decade in several Gram-negative and Gram-positive bacteria of the LuxS protein, which catalyzes production of the AI-2 autoinducer molecule for a second quorum sensing system (QS-2). Since the luxS gene was found to be widespread among the most diverse bacterial taxa, it was hypothesized that AI-2 may constitute the basis of a universal microbial language, a kind of bacterial Esperanto. Many of the studies published in this field have drawn a direct correlation between the occurrence of the luxS gene in a given organism and the presence and functionality of a QS-2 therein. However, rarely hathe existence of potential AI-2 receptors been examined. This is important, since it is now well recognized that LuxS also holds a central role as a metabolic enzyme in the activated methyl cycle which is responsible for the generation of S-adenosyl-L-methionine, the major methyl donor in the cell. |
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Chile | 1 | <1% |
Sweden | 1 | <1% |
Canada | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 168 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 43 | 24% |
Researcher | 36 | 20% |
Student > Master | 16 | 9% |
Student > Bachelor | 13 | 7% |
Student > Doctoral Student | 13 | 7% |
Other | 26 | 15% |
Unknown | 29 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 83 | 47% |
Biochemistry, Genetics and Molecular Biology | 17 | 10% |
Immunology and Microbiology | 13 | 7% |
Chemistry | 7 | 4% |
Environmental Science | 6 | 3% |
Other | 15 | 9% |
Unknown | 35 | 20% |