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Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus

Overview of attention for article published in BMC Medical Genomics, March 2018
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  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

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Title
Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus
Published in
BMC Medical Genomics, March 2018
DOI 10.1186/s12881-018-0553-5
Pubmed ID
Authors

Weiyue Ding, Li Xu, Lejun Zhang, Zhijie Han, Qinghua Jiang, Zhe Wang, Shuilin Jin

Abstract

Large scale association studies have found a significant association between type 2 diabetes mellitus (T2DM) and transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146. However, the quality of data varies greatly, as the studies report inconsistent results in different populations. Hence, we perform this meta-analysis to give a more convincing result. The articles, published from January 1st, 2000 to April 1st, 2017, were identified by searching in PubMed and Google Scholar. A total of 56628 participants (34232 cases and 22396 controls) were included in the meta-analysis. A total of 28 studies were divided into 4 subgroups: Caucasian (10 studies), East Asian (5 studies), South Asian (5 studies) and Others (8 studies). All the data analyses were analyzed by the R package meta. The significant association was observed by using the dominant model (OR = 1.41, CI = 1.36 - 1.47, p < 0.0001), recessive model (OR = 1.58, CI = 1.48 - 1.69, p < 0.0001), additive model(CT vs CC) (OR = 1.34, CI = 1.28-1.39, p < 0.0001), additive model(TT vs CC) (OR = 1.81, CI = 1.69-1.94, p < 0.0001)and allele model (OR = 1.35, CI = 1.31-1.39, p < 0.0001). The meta-analysis suggested that rs7903146 was significantly associated with T2DM in Caucasian, East Asian, South Asian and other ethnicities.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 81 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 21%
Student > Bachelor 17 21%
Student > Ph. D. Student 7 9%
Student > Doctoral Student 4 5%
Student > Postgraduate 3 4%
Other 11 14%
Unknown 22 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 23 28%
Medicine and Dentistry 13 16%
Nursing and Health Professions 4 5%
Social Sciences 3 4%
Agricultural and Biological Sciences 2 2%
Other 11 14%
Unknown 25 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2018.
All research outputs
#15,106,857
of 25,394,764 outputs
Outputs from BMC Medical Genomics
#964
of 2,444 outputs
Outputs of similar age
#183,742
of 348,134 outputs
Outputs of similar age from BMC Medical Genomics
#21
of 55 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,444 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,134 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.