Title |
Adoptive cell therapy with autologous tumor infiltrating lymphocytes and low-dose Interleukin-2 in metastatic melanoma patients
|
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Published in |
Journal of Translational Medicine, August 2012
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DOI | 10.1186/1479-5876-10-169 |
Pubmed ID | |
Authors |
Eva Ellebaek, Trine Zeeberg Iversen, Niels Junker, Marco Donia, Lotte Engell-Noerregaard, Özcan Met, Lisbet Rosenkrantz Hölmich, Rikke Sick Andersen, Sine Reker Hadrup, Mads Hald Andersen, Per thor Straten, Inge Marie Svane |
Abstract |
Adoptive cell therapy may be based on isolation of tumor-specific T cells, e.g. autologous tumor infiltrating lymphocytes (TIL), in vitro activation and expansion and the reinfusion of these cells into patients upon chemotherapy induced lymphodepletion. Together with high-dose interleukin (IL)-2 this treatment has been given to patients with advanced malignant melanoma and impressive response rates but also significant IL-2 associated toxicity have been observed. Here we present data from a feasibility study at a Danish Translational Research Center using TIL adoptive transfer in combination with low-dose subcutaneous IL-2 injections. |
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Demographic breakdown
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Researcher | 35 | 18% |
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