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Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells

Overview of attention for article published in Molecular Cancer, January 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

patent
1 patent
wikipedia
1 Wikipedia page

Citations

dimensions_citation
50 Dimensions

Readers on

mendeley
55 Mendeley
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1 CiteULike
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Title
Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells
Published in
Molecular Cancer, January 2009
DOI 10.1186/1476-4598-8-131
Pubmed ID
Authors

Boon Chua, David Gallego-Ortega, Ana de Molina, Axel Ullrich, Juan Lacal, Julian Downward

Abstract

The serine/threonine kinase PKB/Akt plays essential role in various cellular processes including cell growth and proliferation, metabolism and cell survival. The importance of the Akt pathway is highlighted by the mutation of various components of the pathway such as the PTEN and PI3-kinase (P110alpha) in human cancers. In this paper, we employed an RNA interference library targeting all human kinases to screen for kinases involved in the regulation of Akt activation, in particular serine 473 phosphorylation. Here, we transfected the MDA-MB 468 breast cell line with the human kinome siRNA library and measured Akt activation using an antibody specific for phosphoserine 473 of Akt.

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Spain 1 2%
Italy 1 2%
Unknown 52 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 24%
Researcher 12 22%
Student > Doctoral Student 7 13%
Student > Master 7 13%
Student > Bachelor 4 7%
Other 8 15%
Unknown 4 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 42%
Biochemistry, Genetics and Molecular Biology 11 20%
Medicine and Dentistry 7 13%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Chemistry 2 4%
Other 3 5%
Unknown 5 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2017.
All research outputs
#2,101,719
of 12,247,570 outputs
Outputs from Molecular Cancer
#88
of 1,039 outputs
Outputs of similar age
#54,321
of 272,492 outputs
Outputs of similar age from Molecular Cancer
#5
of 38 outputs
Altmetric has tracked 12,247,570 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,039 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,492 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.