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Fecal microbiota transplantation against intestinal colonization by extended spectrum beta-lactamase producing Enterobacteriaceae: a proof of principle study

Overview of attention for article published in BMC Research Notes, March 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)

Mentioned by

twitter
9 tweeters

Citations

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54 Dimensions

Readers on

mendeley
95 Mendeley
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Title
Fecal microbiota transplantation against intestinal colonization by extended spectrum beta-lactamase producing Enterobacteriaceae: a proof of principle study
Published in
BMC Research Notes, March 2018
DOI 10.1186/s13104-018-3293-x
Pubmed ID
Authors

Ramandeep Singh, Pieter F. de Groot, Suzanne E. Geerlings, Caspar J. Hodiamont, Clara Belzer, Ineke J. M. ten Berge, Willem M. de Vos, Frederike J. Bemelman, Max Nieuwdorp

Abstract

Infections with multidrug-resistant microorganisms are associated with increased hospitalization, medication costs and mortality. Based on our fecal microbiota transplantation (FMT) experience for Clostridium difficile infection, we treated 15 patients carrying ESBL-producing Enterobacteriaceae (ESBL-EB) with FMT. Seven patients underwent a second FMT after 4 weeks when ESBL-EB remained, amounting to a total number of 22 transplants. The objective was decolonization of ESBL-EB. Three out of fifteen (20%) patients were ESBL-negative at 1, 2 and 4 weeks after the first transplant, while six out of 15 (40%) were negative after the second transplant. Comparison of fecal microbiota at baseline and 4 weeks after FMT revealed restoration of microbial diversity after FMT and a microbial shift towards donor composition. Finally, we suggest several possible factors of response to therapy, such as donor-recipient microbiota match and number of FMTs. Therefore, FMT can be an effective treatment in patients carrying ESBL-EB. Response may be determined by microbiota composition and number of FMT procedures. Trial registration ISRCTN ISRCTN48328635 Registered 11 October 2017, retrospectively registered.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 95 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 20%
Student > Bachelor 12 13%
Student > Doctoral Student 10 11%
Student > Master 9 9%
Student > Ph. D. Student 8 8%
Other 14 15%
Unknown 23 24%
Readers by discipline Count As %
Medicine and Dentistry 27 28%
Immunology and Microbiology 8 8%
Agricultural and Biological Sciences 6 6%
Biochemistry, Genetics and Molecular Biology 6 6%
Chemistry 4 4%
Other 10 11%
Unknown 34 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2018.
All research outputs
#3,757,401
of 13,560,184 outputs
Outputs from BMC Research Notes
#666
of 3,079 outputs
Outputs of similar age
#95,613
of 271,293 outputs
Outputs of similar age from BMC Research Notes
#1
of 1 outputs
Altmetric has tracked 13,560,184 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 3,079 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,293 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them