Title |
Fecal microbiota transplantation against intestinal colonization by extended spectrum beta-lactamase producing Enterobacteriaceae: a proof of principle study
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Published in |
BMC Research Notes, March 2018
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DOI | 10.1186/s13104-018-3293-x |
Pubmed ID | |
Authors |
Ramandeep Singh, Pieter F. de Groot, Suzanne E. Geerlings, Caspar J. Hodiamont, Clara Belzer, Ineke J. M. ten Berge, Willem M. de Vos, Frederike J. Bemelman, Max Nieuwdorp |
Abstract |
Infections with multidrug-resistant microorganisms are associated with increased hospitalization, medication costs and mortality. Based on our fecal microbiota transplantation (FMT) experience for Clostridium difficile infection, we treated 15 patients carrying ESBL-producing Enterobacteriaceae (ESBL-EB) with FMT. Seven patients underwent a second FMT after 4 weeks when ESBL-EB remained, amounting to a total number of 22 transplants. The objective was decolonization of ESBL-EB. Three out of fifteen (20%) patients were ESBL-negative at 1, 2 and 4 weeks after the first transplant, while six out of 15 (40%) were negative after the second transplant. Comparison of fecal microbiota at baseline and 4 weeks after FMT revealed restoration of microbial diversity after FMT and a microbial shift towards donor composition. Finally, we suggest several possible factors of response to therapy, such as donor-recipient microbiota match and number of FMTs. Therefore, FMT can be an effective treatment in patients carrying ESBL-EB. Response may be determined by microbiota composition and number of FMT procedures. Trial registration ISRCTN ISRCTN48328635 Registered 11 October 2017, retrospectively registered. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 2 | 22% |
India | 1 | 11% |
Unknown | 6 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 56% |
Scientists | 2 | 22% |
Practitioners (doctors, other healthcare professionals) | 2 | 22% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 108 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 19 | 18% |
Student > Bachelor | 13 | 12% |
Student > Ph. D. Student | 10 | 9% |
Student > Master | 10 | 9% |
Student > Doctoral Student | 9 | 8% |
Other | 18 | 17% |
Unknown | 29 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 29 | 27% |
Immunology and Microbiology | 8 | 7% |
Agricultural and Biological Sciences | 8 | 7% |
Biochemistry, Genetics and Molecular Biology | 7 | 6% |
Chemistry | 4 | 4% |
Other | 12 | 11% |
Unknown | 40 | 37% |