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Fecal microbiota transplantation against intestinal colonization by extended spectrum beta-lactamase producing Enterobacteriaceae: a proof of principle study

Overview of attention for article published in BMC Research Notes, March 2018
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  • Good Attention Score compared to outputs of the same age (66th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

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Title
Fecal microbiota transplantation against intestinal colonization by extended spectrum beta-lactamase producing Enterobacteriaceae: a proof of principle study
Published in
BMC Research Notes, March 2018
DOI 10.1186/s13104-018-3293-x
Pubmed ID
Authors

Ramandeep Singh, Pieter F. de Groot, Suzanne E. Geerlings, Caspar J. Hodiamont, Clara Belzer, Ineke J. M. ten Berge, Willem M. de Vos, Frederike J. Bemelman, Max Nieuwdorp

Abstract

Infections with multidrug-resistant microorganisms are associated with increased hospitalization, medication costs and mortality. Based on our fecal microbiota transplantation (FMT) experience for Clostridium difficile infection, we treated 15 patients carrying ESBL-producing Enterobacteriaceae (ESBL-EB) with FMT. Seven patients underwent a second FMT after 4 weeks when ESBL-EB remained, amounting to a total number of 22 transplants. The objective was decolonization of ESBL-EB. Three out of fifteen (20%) patients were ESBL-negative at 1, 2 and 4 weeks after the first transplant, while six out of 15 (40%) were negative after the second transplant. Comparison of fecal microbiota at baseline and 4 weeks after FMT revealed restoration of microbial diversity after FMT and a microbial shift towards donor composition. Finally, we suggest several possible factors of response to therapy, such as donor-recipient microbiota match and number of FMTs. Therefore, FMT can be an effective treatment in patients carrying ESBL-EB. Response may be determined by microbiota composition and number of FMT procedures. Trial registration ISRCTN ISRCTN48328635 Registered 11 October 2017, retrospectively registered.

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The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 108 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 18%
Student > Bachelor 13 12%
Student > Ph. D. Student 10 9%
Student > Master 10 9%
Student > Doctoral Student 9 8%
Other 18 17%
Unknown 29 27%
Readers by discipline Count As %
Medicine and Dentistry 29 27%
Immunology and Microbiology 8 7%
Agricultural and Biological Sciences 8 7%
Biochemistry, Genetics and Molecular Biology 7 6%
Chemistry 4 4%
Other 12 11%
Unknown 40 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2018.
All research outputs
#6,264,930
of 23,313,051 outputs
Outputs from BMC Research Notes
#939
of 4,306 outputs
Outputs of similar age
#110,019
of 333,295 outputs
Outputs of similar age from BMC Research Notes
#15
of 99 outputs
Altmetric has tracked 23,313,051 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 4,306 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,295 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.