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Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials

Overview of attention for article published in Diabetology & Metabolic Syndrome, March 2018
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Title
Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials
Published in
Diabetology & Metabolic Syndrome, March 2018
DOI 10.1186/s13098-018-0318-5
Pubmed ID
Authors

Maria E. Balbi, Fernanda S. Tonin, Antonio M. Mendes, Helena H. Borba, Astrid Wiens, Fernando Fernandez-Llimos, Roberto Pontarolo

Abstract

Vitamins are essential micronutrients with antioxidant potential that may provide a complementary treatment for patients with chronic diseases. Our aim was to assess the effect of vitamin supplementation on the antioxidant status and glycemic index of type 2 diabetes mellitus patients. We performed a systematic review with meta-analyses. Electronic searches were conducted in PubMed, Scopus, and Web of Science (December 2017). Randomized controlled trials evaluating the effect of any vitamin or vitamin complex supplementation on antioxidant status as primary outcome were included. The outcomes considered were: reduction of malondialdehyde (MDA); augmentation of glutathione peroxidase (GPx); changes in total antioxidant capacity (TAC), enhance in superoxide dismutase enzyme-SOD, and thiobarbituric acid reactive substances (TBARS). Outcomes of glycemic control were also evaluated. Pairwise meta-analyses were performed using software Review Manager 5.3. Thirty trials fulfilled the inclusion criteria, but only 12 could be included in the meta-analyses of antioxidant outcomes. The most commonly studied vitamins were B, C, D and E. Vitamin E was related to significant reduction of blood glucose as well as glycated hemoglobin compared to placebo, while both vitamins C and E were mainly associated with reducing MDA and TBARS and elevating GPx, SOD and TAC, compared to placebo. However, outcome reports in this field are still inconsistent (e.g. because of a lack of standard measures). Supplementation of vitamin E may be a valuable strategy for controlling diabetes complications and enhancing antioxidant capacity. The effects of other micronutrients should be further investigated in larger and well-designed trials to properly place these complementary therapies in clinical practice.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 208 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 208 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 25 12%
Student > Master 22 11%
Researcher 15 7%
Student > Ph. D. Student 15 7%
Student > Doctoral Student 15 7%
Other 39 19%
Unknown 77 37%
Readers by discipline Count As %
Medicine and Dentistry 38 18%
Pharmacology, Toxicology and Pharmaceutical Science 23 11%
Nursing and Health Professions 21 10%
Agricultural and Biological Sciences 12 6%
Biochemistry, Genetics and Molecular Biology 12 6%
Other 13 6%
Unknown 89 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2019.
All research outputs
#14,432,787
of 23,573,233 outputs
Outputs from Diabetology & Metabolic Syndrome
#324
of 710 outputs
Outputs of similar age
#184,877
of 334,623 outputs
Outputs of similar age from Diabetology & Metabolic Syndrome
#12
of 18 outputs
Altmetric has tracked 23,573,233 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 710 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,623 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.