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Erythropoiesis: insights into pathophysiology and treatments in 2017

Overview of attention for article published in Molecular Medicine, March 2018
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  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

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Title
Erythropoiesis: insights into pathophysiology and treatments in 2017
Published in
Molecular Medicine, March 2018
DOI 10.1186/s10020-018-0011-z
Pubmed ID
Authors

Andrea Zivot, Jeffrey M. Lipton, Anupama Narla, Lionel Blanc

Abstract

Erythropoiesis is a tightly-regulated and complex process originating in the bone marrow from a multipotent stem cell and terminating in a mature, enucleated erythrocyte.Altered red cell production can result from the direct impairment of medullary erythropoiesis, as seen in the thalassemia syndromes, inherited bone marrow failure as well as in the anemia of chronic disease. Alternatively, in disorders such as sickle cell disease (SCD) as well as enzymopathies and membrane defects, medullary erythropoiesis is not, or only minimally, directly impaired. Despite these differences in pathophysiology, therapies have traditionally been non-specific, limited to symptomatic control of anemia via packed red blood cell (pRBC) transfusion, resulting in iron overload and the eventual need for iron chelation or splenectomy to reduce defective red cell destruction. Likewise, in polycythemia vera overproduction of red cells has historically been dealt with by non-specific myelosuppression or phlebotomy. With a deeper understanding of the molecular mechanisms underlying disease pathophysiology, new therapeutic targets have been identified including induction of fetal hemoglobin, interference with aberrant signaling pathways and gene therapy for definitive cure. This review, utilizing some representative disorders of erythropoiesis, will highlight novel therapeutic modalities currently in development for treatment of red cell disorders.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 318 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 318 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 47 15%
Student > Master 32 10%
Student > Ph. D. Student 28 9%
Researcher 21 7%
Student > Postgraduate 15 5%
Other 37 12%
Unknown 138 43%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 67 21%
Medicine and Dentistry 45 14%
Agricultural and Biological Sciences 15 5%
Unspecified 9 3%
Immunology and Microbiology 7 2%
Other 32 10%
Unknown 143 45%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 August 2022.
All research outputs
#15,352,327
of 24,337,175 outputs
Outputs from Molecular Medicine
#813
of 1,218 outputs
Outputs of similar age
#192,602
of 335,046 outputs
Outputs of similar age from Molecular Medicine
#8
of 16 outputs
Altmetric has tracked 24,337,175 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,218 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,046 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.