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Mendeley readers
Attention Score in Context
| Title |
The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks
|
|---|---|
| Published in |
BMC Molecular and Cell Biology, September 2005
|
| DOI | 10.1186/1471-2199-6-19 |
| Pubmed ID | |
| Authors |
Gulshan Sunavala-Dossabhoy, Sri Kripa Balakrishnan, Siddhartha Sen, Sam Nuthalapaty, Arrigo De Benedetti |
| Abstract |
The mammalian protein kinase TLK1 is a homologue of Tousled, a gene involved in flower development in Arabidopsis thaliana. The function of TLK1 is not well known, although knockout of the gene in Drosophila or expression of a dominant negative mutant in mouse cells causes loss of nuclear divisions and missegregation of chromosomes probably, due to alterations in chromatin remodeling capacity. Overexpression of TLK1B, a spliced variant of the TLK1 mRNA, in a model mouse cell line increases it's resistance to ionizing radiation (IR) or the radiomimetic drug doxorubicin, also likely due to changes in chromatin remodeling. TLK1B is translationally regulated by the availability of the translation factor eIF4E, and its synthesis is activated by IR. The reason for this mechanism of regulation is likely to provide a rapid means of promoting repair of DSBs. TLK1B specifically phosphorylates histone H3 and Asf1, likely resulting in changes in chromatin structure, particularly at double strand breaks (DSB) sites. |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 4% |
| France | 1 | 2% |
| United Kingdom | 1 | 2% |
| Unknown | 49 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 36% |
| Researcher | 11 | 21% |
| Student > Doctoral Student | 5 | 9% |
| Student > Master | 5 | 9% |
| Professor > Associate Professor | 4 | 8% |
| Other | 5 | 9% |
| Unknown | 4 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 58% |
| Biochemistry, Genetics and Molecular Biology | 12 | 23% |
| Medicine and Dentistry | 5 | 9% |
| Nursing and Health Professions | 1 | 2% |
| Unknown | 4 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2007.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from BMC Molecular and Cell Biology
#334
of 1,233 outputs
Outputs of similar age
#25,528
of 70,855 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#3
of 11 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,855 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.