Title |
CHKA and PCYT1Agene polymorphisms, choline intake and spina bifida risk in a California population
|
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Published in |
BMC Medicine, December 2006
|
DOI | 10.1186/1741-7015-4-36 |
Pubmed ID | |
Authors |
James O Ebot Enaw, Huiping Zhu, Wei Yang, Wei Lu, Gary M Shaw, Edward J Lammer, Richard H Finnell |
Abstract |
Neural tube defects (NTDs) are among the most common of all human congenital defects. Over the last two decades, accumulating evidence has made it clear that periconceptional intake of folic acid can significantly reduce the risk of NTD affected pregnancies. This beneficial effect may be related to the ability of folates to donate methyl groups for critical physiological reactions. Choline is an essential nutrient and it is also a methyl donor critical for the maintenance of cell membrane integrity and methyl metabolism. Perturbations in choline metabolism in vitro have been shown to induce NTDs in mouse embryos. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 17% |
Student > Ph. D. Student | 4 | 17% |
Professor | 3 | 13% |
Professor > Associate Professor | 2 | 9% |
Researcher | 2 | 9% |
Other | 3 | 13% |
Unknown | 5 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 22% |
Medicine and Dentistry | 4 | 17% |
Agricultural and Biological Sciences | 4 | 17% |
Unspecified | 1 | 4% |
Neuroscience | 1 | 4% |
Other | 1 | 4% |
Unknown | 7 | 30% |