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Important parameters for optimized metal nanoparticles-aided electromagnetic field (EMF) effect on cancer

Overview of attention for article published in Cancer Nanotechnology, March 2018
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Title
Important parameters for optimized metal nanoparticles-aided electromagnetic field (EMF) effect on cancer
Published in
Cancer Nanotechnology, March 2018
DOI 10.1186/s12645-018-0038-4
Pubmed ID
Authors

Lawrence Ochoo, Charles Migwi, John Okumu

Abstract

A number of experimental research findings for the metal nanoparticles (NPs)-mediated EMF photothermal therapy of cancer cells show an intriguing trend of the NPs' size-dependent efficacy. This is a phenomenon we find to trend with the light absorption bandwidth behavior (full width at half maximum) of the NPs and the accompanying electric field enhancement. We find that the nanoparticle sizes that have been reported to produce the optimized effect on cancer cells are of minimum absorption bandwidth and optimized electric field magnitude. While the death of cancer cells under the NPs-aided EMF effect has in the past attracted varied interpretations, either as a thermal or non-thermal effect, photothermal effect has gained a wide acceptance due to the exhibited hyperthermia. However, the exhibited trend of the NPs' size-dependent efficacy is beginning to feature as a possible manifestation of other overlooked underlying or synergistic phenomenal conditions. We present a theoretical model and analysis which reveal that the contribution and efficacy of the metal NPs in the destruction of cancer depend partly but significantly on the accompanying electric field intensity enhancement factor and partly on their absorption cross-section. This paper finds that, other than the expected hyperthermia, the metal NPs' sizes for the optimized therapy on cancer cells seem to fulfill other synergistic conditions which need to come to the fore. We find interplay between electric field and thermal effects as independent energy channels where balancing may be important for the optimized EMF effect, in the ratio of about 5:1. The required balancing depends on the absorption bandwidth and absorption cross-section of the NPs, the frequency of EMF used and the relative permittivity of the cancer cells. The NPs' size-dependent efficacy decreases away from the NPs' size of minimum absorption bandwidth, which is around 20 nm for Au NPs or other shapes of equivalent surface area-volume ratio. While the absorption wavelength peak for metal NPs would change with the change of shape, the responsible condition(s) for optimizing the efficacy remains relatively invariable. From the modeling and the analysis of the NPs' size for optimizing the EMF therapy on cancer cells, the ratio of electric field enhancement by metal NPs to the associated thermal effect is a very important factor for efficacy.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 18%
Student > Ph. D. Student 2 18%
Student > Bachelor 1 9%
Student > Master 1 9%
Researcher 1 9%
Other 1 9%
Unknown 3 27%
Readers by discipline Count As %
Materials Science 3 27%
Biochemistry, Genetics and Molecular Biology 2 18%
Medicine and Dentistry 2 18%
Social Sciences 1 9%
Unknown 3 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2018.
All research outputs
#13,856,164
of 17,367,552 outputs
Outputs from Cancer Nanotechnology
#84
of 92 outputs
Outputs of similar age
#216,565
of 286,531 outputs
Outputs of similar age from Cancer Nanotechnology
#1
of 1 outputs
Altmetric has tracked 17,367,552 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 92 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,531 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them